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Series GSE60188 Query DataSets for GSE60188
Status Public on May 19, 2015
Title Regulation of the core pre-mRNA splicing machinery by MYC and PRMT5 is essential to sustain lymphomagenesis [B-cells]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Over-expressed MYC binds to virtually all active promoters within a cell, although with different binding affinities, and modulates gene expression, both positively and negatively. Here, we show that during lymphomagenesis in Eµ-myc transgenic mice, MYC directly up-regulates the transcription of the core snRNP assembly genes, including PRMT5, an arginine methyltransferase, that methylates Sm proteins as an early step in lymphomagenesis. This coordinated regulatory effect is direct and is critical for snRNP biogenesis, the maintenance of effective mRNA splicing and cellular viability in cycling cells, in either fibroblasts or B-cells.
Overall design mRNA profiles of wild type and pre-tumoral eu-myc mice by deep sequencing, in triplicate, using Illumina NextSeq 500
Contributor(s) Low DH
Citation(s) 25970242
Submission date Aug 07, 2014
Last update date May 15, 2019
Contact name Diana HP Low
Organization name Institute of Molecular and Cell Biology
Lab Chromatin, Epigenetics & Differentiation
Street address #03-06, 61 Biopolis Drive, Proteos
City Singapore
ZIP/Postal code 138673
Country Singapore
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (6)
GSM1467261 WT_1
GSM1467262 WT_2
GSM1467263 WT_3
This SubSeries is part of SuperSeries:
GSE61638 Regulation of the core pre-mRNA splicing machinery by MYC and PRMT5 is essential to sustain lymphomagenesis
BioProject PRJNA257704
SRA SRP045324

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Supplementary file Size Download File type/resource
GSE60188_fpkm.txt.gz 533.1 Kb (ftp)(http) TXT
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Processed data are available on Series record

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