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Series GSE60121 Query DataSets for GSE60121
Status Public on Jul 18, 2017
Title Mistranslation accelerates the evolution of antifungal drug resistance in Candida albicans [Gene expression]
Organism Candida albicans
Experiment type Expression profiling by array
Summary The fungal pathogen Candida albicans and other pathogens of the CTG clade reassigned the leucine CUG codon to serine and tolerate highly variable levels of both serine and leucine at CUG positions in response to environmental cues. Previous studies found that increased leucine misincorporation levels enhance resistance to drugs but the underlying mechanisms are not known. To clarify the biological role of this tuneable codon ambiguity, we evolved C. albicans strains engineered to mistranslate CUG at elevated levels, in the presence and absence of the antifungal drug fluconazole
 
Overall design Expression profiling was performed on evolved C. albicans strains engineered to mistranslate CUG at elevated levels, in the presence and absence of the antifungal drug fluconazole at three different timepoints.
 
Contributor(s) Weil T, SantamarĂ­a R
Citation(s) 28808688
Submission date Aug 05, 2014
Last update date Oct 17, 2017
Contact name Tobias Weil
E-mail(s) tobias.weil@fmach.it
Organization name Fondazione Edmund Mach
Street address Via E. Mach, 1
City S. Michele all'Adige (TN)
ZIP/Postal code 38010
Country Italy
 
Platforms (1)
GPL19049 Agilent-024282 Candida albicans 1245169391301
Samples (16)
GSM1465299 t0_fluc_beg_rep1
GSM1465300 t0_fluc_beg_rep2
GSM1465301 t1_fluc_beg_rep1
This SubSeries is part of SuperSeries:
GSE60122 Mistranslation accelerates the evolution of antifungal drug resistance in Candida albicans
Relations
BioProject PRJNA257518

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE60121_RAW.tar 20.8 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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