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Series GSE60065 Query DataSets for GSE60065
Status Public on Aug 31, 2014
Title Chronic Myeloid Leukemia (CML), induced pluripotent stem cell (iPSC)-derived lin-CD34+CD45+ (iCD34) cell population
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Analysis of lin-CD34+CD45+ (iCD34+) cell population from two normal bone marrow-derived (BM1K and BM9) iPSCs and two CML (CML15 and CML17) iPSCs . CML iCD34+ cells have characteristics similar to primary CML leukemia stem cell in patients. Results provide insight into molecular profile characterized CML iCD34 and mechanism of its maintenance and drug resistance.
Overall design iCD34+ cell samples obtained from two control BM1K and BM9 iPSCs (both for the same normal donor) and CML15 and CML17 iPSCs (both from the same patient in chronic phase of CML). Each group was treated with DMSO (control) or 5 μM imatinib. The complete phenotype for iCD34+ cells: lin-CD34+CD45+CD90+CD117+CD45RA-. This population also inclyde Rhodaminelow and ALDKhigh cells.
Contributor(s) Suknuntha K, Slukvin I, Swanson S
Citation(s) 26561938
Submission date Aug 04, 2014
Last update date Jul 18, 2019
Contact name Scott Swanson
Organization name Morgridge Institute for Research
Lab Thomson
Street address 330 N. Orchard St
City Madison
State/province WI
ZIP/Postal code 53715
Country USA
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (8)
GSM1464525 BM1K iCD34+ Control
GSM1464526 BM9 iCD34+ Control
GSM1464527 CML15 iCD34+ Control
BioProject PRJNA257403
SRA SRP045234

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Supplementary file Size Download File type/resource 379.2 Kb (ftp)(http) TAB 436.3 Kb (ftp)(http) TAB 347.4 Kb (ftp)(http) TAB
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