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| Status |
Public on Aug 02, 2014 |
| Title |
Genome-wide maps of HES1 binding-site in human chondrogenic cell. |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Notch signaling modulates skeletal formation and osteoarthritis (OA) development through induction of catabolic factors. Here we examined functional roles of Hes1, the representative downstream transcription factor of Notch signaling, during these processes. Chromatin immunoprecipitation-sequencing (ChIP-seq) identified resposive elements of Hes1 around gene loci of Mmp13 and Adamts5, which were catabolic enzymes of cartilage matrix.
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| Overall design |
Examination of HES1 binding site in human chondrogenic SW1353 cells.
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| Contributor(s) |
Sugita S, Saito T |
| Citation(s) |
25733872 |
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| Submission date |
Aug 01, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Shurei Sugita |
| E-mail(s) |
ssugita-tky@umin.ac.jp
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| Organization name |
The University of Tokyo
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| Department |
Sensory & Motor System Medicine
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| Street address |
7-3-1, Hongo, Bunkyo-ku
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| City |
Tokyo |
| ZIP/Postal code |
113-8655 |
| Country |
Japan |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (1) |
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| Relations |
| BioProject |
PRJNA257267 |
| SRA |
SRP045174 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE60006_RAW.tar |
1.3 Gb |
(http)(custom) |
TAR (of BED, BEDGRAPH, XLSX) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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