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Series GSE59576 Query DataSets for GSE59576
Status Public on Jul 18, 2015
Title ATM deficiency in the absence of T cells promotes the development of NF-kB-dependent B cell lymphomas [Gene Expression]
Organism Mus musculus
Experiment type Expression profiling by array
Summary Our model removes T cells as targets for lymphomagenesis as well as eliminating T cell-dependent immune surveillance. These mice exclusively develop early onset IgM+ B cell lymphomas that histologically and genetically resemble the activated B cell-like (ABC) subset of human diffuse large B cell lymphomas (DLBCL).
This dataset includes the comparison of B-cell lymphomas (tumors) from ATMKO.CD3eKO RNA expression levels with normal spleens from both ATMKO.CD3eKO and ATMWT.CD3eKO non-tumor bearing mice.
Overall design Ten ATMKO.CD3╬ÁKO B cell lymphoma cell lines were established from tumor-bearing spleen cells. As per comparison to normal tissue, seven spleens from ATMWT.CD3eKO mice and six non-tumor bearing spleens from a ATMKO.CD3eKO mice were used. RNA quality was assessed by Bioanalyzer and only those samples with RIN higher than 8 were used.
Contributor(s) Hathcock KS, Padilla-Nash HM, Camps J, Shin D, Triner D, Maul RW, Steinberg SM, Gearhart PJ, Morse III HC, Ried T, Hodes RJ
Citation(s) 26400962
Submission date Jul 18, 2014
Last update date Jan 12, 2017
Contact name Jordi Camps
Organization name IDIBAPS / Hospital Clinic
Department Gastroenterology
Lab Gastrointestinal and Pancreatic Oncology
Street address c/Rossell├│ 149-153 4th floor, Center Esther Koplowitz
City Barcelona
State/province Catalonia
ZIP/Postal code 08036
Country Spain
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (23)
GSM1439622 178119_BCL
GSM1439623 285487_BCL
GSM1439624 47990_BCL
This SubSeries is part of SuperSeries:
GSE59578 ATM deficiency in the absence of T cells promotes the development of NF-kB-dependent B cell lymphomas
BioProject PRJNA255765

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE59576_RAW.tar 50.2 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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