|Public on Jul 18, 2015
|ATM deficiency in the absence of T cells promotes the development of NF-kB-dependent B cell lymphomas [Gene Expression]
|Expression profiling by array
|Our model removes T cells as targets for lymphomagenesis as well as eliminating T cell-dependent immune surveillance. These mice exclusively develop early onset IgM+ B cell lymphomas that histologically and genetically resemble the activated B cell-like (ABC) subset of human diffuse large B cell lymphomas (DLBCL).
This dataset includes the comparison of B-cell lymphomas (tumors) from ATMKO.CD3eKO RNA expression levels with normal spleens from both ATMKO.CD3eKO and ATMWT.CD3eKO non-tumor bearing mice.
|Ten ATMKO.CD3εKO B cell lymphoma cell lines were established from tumor-bearing spleen cells. As per comparison to normal tissue, seven spleens from ATMWT.CD3eKO mice and six non-tumor bearing spleens from a ATMKO.CD3eKO mice were used. RNA quality was assessed by Bioanalyzer and only those samples with RIN higher than 8 were used.
|Hathcock KS, Padilla-Nash HM, Camps J, Shin D, Triner D, Maul RW, Steinberg SM, Gearhart PJ, Morse III HC, Ried T, Hodes RJ
|Jul 18, 2014
|Last update date
|Jan 12, 2017
|IDIBAPS / Hospital Clinic
|Gastrointestinal and Pancreatic Oncology
|c/Rosselló 149-153 4th floor, Center Esther Koplowitz
|Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
|This SubSeries is part of SuperSeries:
|ATM deficiency in the absence of T cells promotes the development of NF-kB-dependent B cell lymphomas