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Status |
Public on Jul 15, 2014 |
Title |
Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia |
Organism |
Mus musculus |
Experiment type |
Genome variation profiling by array
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Summary |
T-ALL cell lines versus Bl57/6J spleen We investigated how RTK signaling might contribute to T-ALL using an established bone marrow transplantation model. To mimick tyrosine kinase signalling we expressed a constitutively active form of the TRKA receptor tyrosine kinase (ΔTrkA) in hematopoietic progenitor cells. Mice transplanted with ΔTrkA transduced cells developed T-ALL with a high penetrance.
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Overall design |
comparative hybridization of DNA from T-ALL clones versus reference DNA (spleen)
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Contributor(s) |
Steinemann D, Schwarzer A |
Citation(s) |
25241901 |
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Submission date |
Jul 14, 2014 |
Last update date |
Oct 14, 2014 |
Contact name |
Doris Johanna Steinemann |
E-mail(s) |
steinemann.doris@mh-hannover.de
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Phone |
+495115324669
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Organization name |
Hannover Medical School
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Department |
Institute of Human Genetics
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Lab |
Array-Lab
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Street address |
Carl-Neuberg-Str.1
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City |
Hannover |
ZIP/Postal code |
30625 |
Country |
Germany |
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Platforms (1) |
GPL10449 |
Agilent-027411 SurePrint G3 Mouse CGH Microarray 4x180K (Feature Number version) |
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Samples (6)
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Relations |
BioProject |
PRJNA255201 |