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Series GSE59246 Query DataSets for GSE59246
Status Public on Jul 07, 2016
Title Molecular features of subtype-specific progression from ductal carcinoma in situ to invasive breast cancer [gene expression data]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Breast cancer consists of at least five main molecular “intrinsic” subtypes, which are reflected in both pre-invasive and invasive disease. Although previous studies have suggested that many of the molecular features of invasive breast cancer are established early, it is unclear what mechanisms drive progression, and whether the mechanisms of progression are dependent or independent of subtype. We have generated mRNA, miRNA and DNA copy number profiles from a total of 59 in situ lesions and 85 invasive tumors, in order to comprehensively identify those genes, signaling pathways, processes, and cell types that are involved in breast cancer progression. Our work provides evidence that there are molecular features associated with disease progression that are unique to the intrinsic subtypes. We additionally establish subtype-specific signatures that are able to identify a small proportion of pre-invasive tumors with expression profiles that resemble invasive carcinoma, indicating a higher likelihood of future disease progression.
Overall design One-color design, totaling 105 arrays and 103 unique tissues. Arrays consist of 3 normal controls (1 unique), 46 DCIS lesions (46 unique), and 56 small invasive breast cancers (56 unique).
Contributor(s) Lesurf R, Aure MR, Mørk HH, Vitelli V, Lundgren S, Børresen-Dale A, Kristensen V, Wärnberg F, Hallett M, Sørlie T
Citation(s) 27396337
Submission date Jul 09, 2014
Last update date Nov 27, 2018
Contact name Robert Lesurf
Organization name Washington University in St. Louis
Department McDonnell Genome Institute
Lab Griffith Lab
Street address 4444 Forest Park Ave
City St. Louis
State/province MO
ZIP/Postal code 63112
Country USA
Platforms (1)
GPL13607 Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version)
Samples (105)
GSM1431259 DCIS-FW08_400
GSM1431260 DCIS-FW06_23
GSM1431261 IBC-FW06_68
This SubSeries is part of SuperSeries:
GSE59248 Molecular features of subtype-specific progression from ductal carcinoma in situ to invasive breast cancer
BioProject PRJNA254806

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE59246_RAW.tar 1.3 Gb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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