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Series GSE58885 Query DataSets for GSE58885
Status Public on Dec 19, 2014
Title Methylomic trajectories across human fetal brain development
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Dynamic changes to the epigenome mediate key neurobiological and cognitive processes in the central nervous system, and also play a role in transcriptional regulation during brain development. Although the importance of DNA methylation in brain development is highlighted by the neurodevelopmental deficits associated with mutations in genes including methyl-CpG binding protein 2 (MECP2), our knowledge about the specific methylomic trajectories associated with human neurodevelopment is extremely limited. Here we report an analysis of genome-wide patterns of DNA methylation in 179 human fetal brain samples.
Overall design Bisulphite converted DNA from 179 human brain samples was hybridized to the Illumina 450K Human Methylation Beadchip.
Contributor(s) Spiers H, Hannon E, Schalkwyk L, Wong C, Smith R, O'Donovan M, Bray N, Mill J
Citation(s) 25650246
Submission date Jun 27, 2014
Last update date Mar 22, 2019
Contact name Jon Mill
Organization name King's College London
Department Institute of Psychiatry
Lab MRC SGDP Centre
Street address De Crespigny Park
City London
ZIP/Postal code SE5 8AF
Country United Kingdom
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (179)
GSM1421432 Human Fetal Brain (8963303124_R01C01)
GSM1421433 Human Fetal Brain (8963303124_R01C02)
GSM1421434 Human Fetal Brain (8963303124_R02C01)
BioProject PRJNA253824

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE58885_RAW.tar 183.1 Mb (http)(custom) TAR
GSE58885_methylated_unmethylated_non_processed.txt.gz 379.3 Mb (ftp)(http) TXT
Processed data included within Sample table

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