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Series GSE58783 Query DataSets for GSE58783
Status Public on Jul 06, 2021
Title Retinoblastoma genome methylation data
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Retinoblastoma is the most common intraocular cancer of infancy and childhood, with an incidence of one case per 15,000 - 20,000 live births. An early event in retinoblastoma genesis is a functional loss of both alleles of the RB1 gene. However, other genes are likely to be involved in the development of this cancer. In this study we sought to build a comprehensive molecular portrait of this cancer by performing transcriptomic, methylomic, genomic profiling of primary retinoblastoma samples. Most of the patients whose tumors were studied had received no treatment prior to surgical enucleation.
Overall design Immediately following enucleation, a needle was inserted through the eye's anterior chamber to extract a tumor sample by aspiration; the tumor specimen was then snap frozen. For these arrays, DNA was extracted from these snap frozen samples.
We used Illumina HumanMethylation450 BeadChip arrays to study the genome methylation patterns of 67 primary retinoblastoma tumors and 3 foetal retina samples.
Contributor(s) Radvanyi F, Sefta M, Ottaviani D, Desbrousses C, Liu J, Chapeaublanc E
Citation(s) 34552068
Submission date Jun 24, 2014
Last update date Jan 28, 2022
Contact name Elodie chapeaublanc
Organization name Institut Curie
Department UMR 144
Lab Equipe Radvanyi
Street address 26 rue d'ulm
City paris
ZIP/Postal code 75248
Country France
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (74)
GSM5123243 RB1 (methylation)
GSM5123244 RB2 (methylation)
GSM5123245 RB3 (methylation)
This SubSeries is part of SuperSeries:
GSE58785 Pan-genomic study of primary human retinoblastoma samples
BioProject PRJNA253483

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE58783_Methylation_processed_data.RData.gz 290.1 Mb (ftp)(http) RDATA
GSE58783_Methylation_raw_data.RData.gz 383.0 Mb (ftp)(http) RDATA
GSE58783_RAW.tar 788.6 Mb (http)(custom) TAR (of IDAT)
GSE58783_Raw_data_i_methylation_retino_all_samples.csv.gz 627.3 Mb (ftp)(http) CSV
GSE58783_processed_data_i_methylation_retino_all_samples.csv.gz 324.1 Mb (ftp)(http) CSV
Processed data are available on Series record

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