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Series GSE58618 Query DataSets for GSE58618
Status Public on Sep 10, 2015
Title Genome-wide DNA methylation analyses by the MeDIP assay
Organism Mus musculus
Experiment type Methylation profiling by high throughput sequencing
Summary We analyzed the genome-wide DNA methylation in Zscan4 overexpressing ES cells. Zscan4 overexpression induced slight DNA demethylation in telomere and major satellite regions. Subsequent genome-wide analysis of non-repeated regions revealed the significant reduction of DNA methylation at Zscan4-dependent hyperacetylation sites. This result indicates that Zscan4 is not only a marker of the Zscan4+ state of ES cells, but also indispensable for the dramatic epigenetic modifications occurring in the Zscan4+ state.
Overall design DNA methylation in Zscan4 overexresssing ES cells
Contributor(s) Xin L, Sharov A, Qian Y
Citation(s) 26324425
Submission date Jun 18, 2014
Last update date May 15, 2019
Contact name Minoru S.H. Ko
Phone 410-558-8359
Organization name NIH
Department National Institute on Aging
Lab Lab of Genetics
Street address 251 Bayview Blvd, Suite 100, 10C
City Baltimore
State/province MD
ZIP/Postal code 21224
Country USA
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (2)
GSM1415499 tet-Zscan4 ES cells (Dox+; Zscan4-)
GSM1415500 tet-Zscan4 ES cells (Dox-; Zscan4+)
This SubSeries is part of SuperSeries:
GSE51682 Zscan4 mediates transient remodeling and transcriptional burst of heterochromatin in mouse embryonic stem cells
BioProject PRJNA253028
SRA SRP043375

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Supplementary file Size Download File type/resource
GSE58618_meDID_Zscan4_induction.txt.gz 310.1 Kb (ftp)(http) TXT
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