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Series GSE58477 Query DataSets for GSE58477
Status Public on Jul 31, 2014
Title Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary The study investigated the abberrent DNA methylation in correlation with gene expression in cytogenetic normal acute myeloid leukemia. CN-AML blasts isolated from patient bone marrow aspriation were compared to CD34+ cell population from healthy donors by DNA methylation array and affymetrix gene expression microarray.
Overall design Bisulfited genomic DNA from patients and normal materials were hybirdized to Illumia Infinium Human Methylation 450K Beadchip. Gene expression profiling on selected patient cohort are publish aviable.
Contributor(s) Qu Y, Lennartsson A, I.Gaidzik V, Deneberg S, Karimi M, Bengtzén S, Höglund M, Bullinger L, Döhner K, Lehmann S
Citation(s) 24866170
Submission date Jun 13, 2014
Last update date Mar 22, 2019
Contact name Ying Qu
Organization name Karolinska Institute
Department Department of Medicine, Huddinge
Lab Center of Hematology and Regenerative Medicine (HERM)
Street address Hälsovagen 7
City Stockholm
State/province Stockholm
ZIP/Postal code 14157
Country Sweden
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (72)
GSM1412245 genomic DNA from bone marrow CD34+ cells 5729917060_RO3CO2
GSM1412246 genomic DNA from bone marrow CD34+ cells 5729917060_RO4CO2
GSM1412247 genomic DNA from bone marrow CD34+ cells 5729917060_RO5CO2
BioProject PRJNA252724

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE58477_RAW.tar 183.1 Mb (http)(custom) TAR
GSE58477_signal_intensities.txt.gz 176.6 Mb (ftp)(http) TXT
Processed data included within Sample table

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