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| Status |
Public on Aug 26, 2014 |
| Title |
NQO1 regulates inflammatory signaling |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
NQO1 silencing by a specific shRNA against NQO1 increased migration and hormone-independent survival in hormone-dependent human prostate cancer cells LNCaP. Genome wide array revealed that NQO1 blockade significantly upregulated pro-inflammatory mediators (e.g., IL-32, CCL2, IL-8, IL-17C, IL-10RA, CXCR2, CXCR7, NOS3) associated with prostate tumorigenesis.
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| Overall design |
Two-condition experiment, control vs. NQO1 knockdown LNCaP cells. Biological replicates: 3 control replicates, 3 NQO1 knockdown replicates.
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| Contributor(s) |
Thapa D, Meng P, Bedolla RG, Reddick RL, Kumar AP, Ghosh R |
| Citation(s) |
25125658 |
| Submission date |
Jun 09, 2014 |
| Last update date |
Nov 27, 2018 |
| Contact name |
Rita Ghosh |
| E-mail(s) |
GHOSHR@UTHSCSA.EDU
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| Phone |
(210) 562-4117
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| Organization name |
University of Texas Health Science Center at San Antonio
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| Department |
Urology
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| Street address |
8403 Floyd Curl Drive
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| City |
San Antonio |
| State/province |
TX |
| ZIP/Postal code |
78229 |
| Country |
USA |
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| Platforms (1) |
| GPL13607 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version) |
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| Samples (3) |
| GSM1407403 |
NQO1 knockown vs control LNCaP cells Replicate 1 |
| GSM1407404 |
NQO1 knockown vs control LNCaP cells Replicate 2 |
| GSM1407405 |
NQO1 knockown vs control LNCaP cells Replicate 3 |
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| Relations |
| BioProject |
PRJNA252018 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE58336_RAW.tar |
68.2 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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