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Series GSE58336 Query DataSets for GSE58336
Status Public on Aug 26, 2014
Title NQO1 regulates inflammatory signaling
Organism Homo sapiens
Experiment type Expression profiling by array
Summary NQO1 silencing by a specific shRNA against NQO1 increased migration and hormone-independent survival in hormone-dependent human prostate cancer cells LNCaP. Genome wide array revealed that NQO1 blockade significantly upregulated pro-inflammatory mediators (e.g., IL-32, CCL2, IL-8, IL-17C, IL-10RA, CXCR2, CXCR7, NOS3) associated with prostate tumorigenesis.
Overall design Two-condition experiment, control vs. NQO1 knockdown LNCaP cells. Biological replicates: 3 control replicates, 3 NQO1 knockdown replicates.
Contributor(s) Thapa D, Meng P, Bedolla RG, Reddick RL, Kumar AP, Ghosh R
Citation(s) 25125658
Submission date Jun 09, 2014
Last update date Nov 27, 2018
Contact name Rita Ghosh
Phone (210) 562-4117
Organization name University of Texas Health Science Center at San Antonio
Department Urology
Street address 8403 Floyd Curl Drive
City San Antonio
State/province TX
ZIP/Postal code 78229
Country USA
Platforms (1)
GPL13607 Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version)
Samples (3)
GSM1407403 NQO1 knockown vs control LNCaP cells Replicate 1
GSM1407404 NQO1 knockown vs control LNCaP cells Replicate 2
GSM1407405 NQO1 knockown vs control LNCaP cells Replicate 3
BioProject PRJNA252018

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE58336_RAW.tar 68.2 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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