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Series GSE58306 Query DataSets for GSE58306
Status Public on Aug 31, 2014
Title Gene expression changes in mouse pancreatic cancer xenograft induced by exposure to enriched environment
Organism Mus musculus
Experiment type Expression profiling by array
Summary Previous studies reported that mice living in an enriched environment (EE) showed reduced growth of melanoma, colon and breast tumors. Our study extended the potential anti-tumor effect of EE exposure to pancreatic cancer, and firstly provided evidence demonstrating that EE exposure significantly inhibits tumor growth in a syngeneic murine model of pancreatic cancer. To further investigate the mechanisms underlying the EE-induced pancreatic tumor inhibition, we analyzed the gene expression changes in pancreatic tumor xenograft using an integrative transcriptomic and proteomic approach. Our results found that EE largely decreased the expression of genes associated with mitochondrial function at transcriptional level in pancreatic tumor, suggesting mitochondrial dysfunction in tumor cells may play a critical role in EE-induced anti-tumor phenotype.
 
Overall design Three-week-old C57BL/6 mice were randomized to live in either enriched environment or standard environment conditions. Mice from both groups were given subcutaneous injection of Panc02 murine pancreatic cancer cells (6 × 105 cells per mouse) and lived in their respective homes for 5 additional weeks. Pooled RNA samples extracted from Panc02 tumors (6 mice for each group) were then subjected to Agilent-014868 Whole Mouse Genome 4☓44k Microarray analyses.
 
Contributor(s) Tu H, Gan Y, Li G
Citation(s) 25598223
Submission date Jun 09, 2014
Last update date Jan 12, 2017
Contact name Yu Gan
E-mail(s) ganyu@shsci.org
Organization name Shanghai Cancer Institute
Lab State Key Laboratory of Oncogenes and Related Genes
Street address 25/Ln. 2200 Xietu Road
City Shanghai
ZIP/Postal code 200032
Country China
 
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (2)
GSM1406255 Panc02_Standard Environment_Pooled RNA
GSM1406256 Panc02_Enriched Environment_Pooled RNA
Relations
BioProject PRJNA251964

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE58306_RAW.tar 15.9 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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