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Series GSE58108 Query DataSets for GSE58108
Status Public on Mar 24, 2015
Title Rlf, a widely-spaced zinc finger protein, is involved in maintaining epigenetic marks at CpG island shores and enhancer elements across the genome
Organism Mus musculus
Experiment type Methylation profiling by high throughput sequencing
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary We recently identified a novel protein, Rearranged L-myc fusion (Rlf), that is required for DNA hypomethylation (and transcriptional activity) at certain regions of the mouse genome known to be sensitive to epigenetic gene silencing. Here we report the analysis of 12 whole genome bisulphite sequencing datasets across three different embryonic tissues/stages from mice with and without Rlf. We find that its absence has effects at thousands of differentially methylated regions.
Overall design Whole genome bilsulphite sequencing, RNAseq and H3K4me1 ChIP-seq for wild type and mice homozygous null for Rlf (MommeD28/MommeD28)
Contributor(s) Whitelaw E, Oey H, Harten S
Citation(s) 25857663
Submission date May 29, 2014
Last update date Oct 17, 2019
Contact name Harald Oey
Organization name La Trobe University
Department Genetics
Street address Kingsbury Drive
City Bundoora
State/province Vic
ZIP/Postal code 3086
Country Australia
Platforms (2)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (22)
GSM1400924 Wildtype E10.5 embryo rep1
GSM1400925 Wildtype E10.5 embryo rep2
GSM1400926 MommeD28/MommeD28 mutant E10.5 embryo rep1
BioProject PRJNA248920
SRA SRP042409

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE58108_RAW.tar 2.2 Gb (http)(custom) TAR (of BW, TAB)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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