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Series GSE57894 Query DataSets for GSE57894
Status Public on May 23, 2014
Title Towards epigenetic understanding and therapy of insulin resistance by intranuclear insulin [DNA methylation]
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary There is evidence indicating the involvement of DNA methylation memory in maintaining gene expression patterns associated with insulin resistance. Although the exact mechanism remains unknown, it has been proved that insulin resistance is correlated to low heat shock protein (HSP) expression.
We reveal that intranuclear insulin can reduce HSP DNA methylation level to up-regulate HSP protein expression and result in long term cure of hyperglycemia.
Overall design Insulin resistance HepG2 cell were selected in our experiments.Two conditions were compared with three replicates each. These are:(1) Insulin resistance HepG2(R-HepG2) and (2) Biomineralized insulin treated HepG2 (BI).
Contributor(s) Xiao Y, Li Z, Cheng Y, Tang R
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Submission date May 22, 2014
Last update date Mar 22, 2019
Contact name Yun Xiao
Organization name Zhejiang University
Street address Yuhangtang Road
City Hangzhou
ZIP/Postal code 310058
Country China
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (6)
GSM1396619 genomic DNA from R-HepG2_1
GSM1396620 genomic DNA from R-HepG2_2
GSM1396621 genomic DNA from R-HepG2_3
This SubSeries is part of SuperSeries:
GSE57928 Towards epigenetic understanding and therapy of insulin resistance by intranuclear insulin
BioProject PRJNA248375

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE57894_RAW.tar 183.1 Mb (http)(custom) TAR
GSE57894_methylated_unmethylated_signal.txt.gz 15.1 Mb (ftp)(http) TXT
Processed data included within Sample table

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