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| Status |
Public on May 23, 2014 |
| Title |
Towards epigenetic understanding and therapy of insulin resistance by intranuclear insulin [DNA methylation] |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
There is evidence indicating the involvement of DNA methylation memory in maintaining gene expression patterns associated with insulin resistance. Although the exact mechanism remains unknown, it has been proved that insulin resistance is correlated to low heat shock protein (HSP) expression.
We reveal that intranuclear insulin can reduce HSP DNA methylation level to up-regulate HSP protein expression and result in long term cure of hyperglycemia.
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| Overall design |
Insulin resistance HepG2 cell were selected in our experiments.Two conditions were compared with three replicates each. These are:(1) Insulin resistance HepG2(R-HepG2) and (2) Biomineralized insulin treated HepG2 (BI).
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| Contributor(s) |
Xiao Y, Li Z, Cheng Y, Tang R |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 22, 2014 |
| Last update date |
Mar 22, 2019 |
| Contact name |
Yun Xiao |
| E-mail(s) |
xy91269264@163.com
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| Organization name |
Zhejiang University
|
| Street address |
Yuhangtang Road
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| City |
Hangzhou |
| ZIP/Postal code |
310058 |
| Country |
China |
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| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE57928 |
Towards epigenetic understanding and therapy of insulin resistance by intranuclear insulin |
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| Relations |
| BioProject |
PRJNA248375 |
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