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| Status |
Public on May 13, 2014 |
| Title |
Correlation of gene expression with bladder capacity in interstitial cystitis/bladder pain syndrome |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Interstitial cystitis (IC) and bladder pain syndrome are terms used to describe a heterogenous chronic pelvic and bladder pain disorder of unknown etiology. The goal of this pilot study was to determine if gene expression profiling of bladder biopsy tissue from patients experiencing symptoms could be used to separate the patients based on some clinical parameter.
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| Overall design |
Gene expression profiles in bladder biopsy tissue from patients with: (1) low bladder capacity (defined here as <400 ml upon hydordistension), (2) normal capacity (≥400 ml), and (3) controls were compared. Gene expression profiles from low bladder capacity tissues differed significantly from normal capacity and control tissue, suggesting gene expression profiling may be a useful tool for better understanding IC disease pathophysiology.
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| Contributor(s) |
Colaco M, Koslov DS, Keys T, Evans RJ, Badlani GH, Erik-Andersson K, Walker SJ |
| Citation(s) |
24840534, 26484132 |
| |
| Submission date |
May 12, 2014 |
| Last update date |
Mar 27, 2018 |
| Contact name |
Stephen Walker |
| E-mail(s) |
swalker@wakehealth.edu
|
| Organization name |
Wake Forest University Health Sciences
|
| Street address |
Medical Center Blvd
|
| City |
Winston Salem |
| ZIP/Postal code |
27157 |
| Country |
USA |
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| Platforms (1) |
| GPL16699 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA246701 |
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