|
| Status |
Public on Feb 03, 2015 |
| Title |
Genome-wide map of Gata6 DNA binding in mouse pancreas |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We have previously described in mouse models that pancreas-specific deletion of Gata6 results in pancreas alterations by rendering pancreatic acinar cells in a non-fully differentiation state, and furthermore it accelerates tumor initiation and progression in a pro-tumorigenic context (KrasG12V expression). We aim to determine the sites where Gata6 binds at the genome-wide level in the pancreas to unveil why its loss leads to altered pancreatic function and enhanced tumor formation when coexpressed with KrasG12V.
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| |
|
| Overall design |
Gata6 ChIP-Seq in the mouse pancreas
|
| |
|
| Contributor(s) |
Madriles F, Martinelli P, Carrillo E, Real F |
| Citation(s) |
25596178 |
| Submission date |
Apr 25, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Francesc Madriles |
| E-mail(s) |
fmadriles@cnio.es
|
| Organization name |
CNIO
|
| Department |
Cancer Cell Biology
|
| Lab |
Epithelial Carcinogenesis
|
| Street address |
c/ Melchor Fernandez Almagro, 3
|
| City |
Madrid |
| State/province |
Madrid |
| ZIP/Postal code |
28029 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
|
| Samples (5)
|
|
| Relations |
| BioProject |
PRJNA245414 |
| SRA |
SRP041453 |
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