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Series GSE57090 Query DataSets for GSE57090
Status Public on Feb 03, 2015
Title Genome-wide map of Gata6 DNA binding in mouse pancreas
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We have previously described in mouse models that pancreas-specific deletion of Gata6 results in pancreas alterations by rendering pancreatic acinar cells in a non-fully differentiation state, and furthermore it accelerates tumor initiation and progression in a pro-tumorigenic context (KrasG12V expression). We aim to determine the sites where Gata6 binds at the genome-wide level in the pancreas to unveil why its loss leads to altered pancreatic function and enhanced tumor formation when coexpressed with KrasG12V.
Overall design Gata6 ChIP-Seq in the mouse pancreas
Contributor(s) Madriles F, Martinelli P, Carrillo E, Real F
Citation(s) 25596178
Submission date Apr 25, 2014
Last update date May 15, 2019
Contact name Francesc Madriles
Organization name CNIO
Department Cancer Cell Biology
Lab Epithelial Carcinogenesis
Street address c/ Melchor Fernandez Almagro, 3
City Madrid
State/province Madrid
ZIP/Postal code 28029
Country Spain
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (5)
GSM1375132 Gata6 ChIP-Seq replicate1
GSM1375133 Gata6 ChIP-Seq replicate2
GSM1375134 Gata6 ChIP-Seq replicate3
BioProject PRJNA245414
SRA SRP041453

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE57090_GATA6_FDR1.bed.gz 72.4 Kb (ftp)(http) BED
GSE57090_Gata6_unique_norm.wig.gz 21.0 Mb (ftp)(http) WIG
GSE57090_RAW.tar 55.6 Mb (http)(custom) TAR (of WIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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