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Series GSE56933 Query DataSets for GSE56933
Status Public on Jul 13, 2016
Title Mismatch between mtDNA and nuclear DNA determines metabolism and healthy aging
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We postulate here that the two singular characteristics of the mitochondrial oxidative phosphorylation system—the integration of three potentially antagonistic functions in the same structure and the double genetic origin of the components that assemble together in these molecular machines—make the evolution of an optimal system impossible. As a consequence the system is intrinsically mismatched and has to be continuously monitored, Adjusted and regulated in order to achieve the necessary and variable performance. Systematic transcriptomic, Metabolomic and biochemical evaluation of animals with identical nuclear DNA but different mtDNA haplotype strongly support the existence of intrinsic mismatch and reveals profound lifelong metabolic consequences on reactive oxygen species generation, Insulin signaling, Tendency towards obesity, And healthy ageing parameters, Including telomere atresia
Overall design Transcriptome analysis of conplastic mice versus WT mice in Liver and Heart tissues
Conplastic strains were obtained after 10 generations of backcrossing to create a new line harboring the nuclear genome of one strain and the mtDNA of another (C57BL/6 and NZB were purchased from Harlan Laboratories).
Contributor(s) Enriquez JA, Latorre A
Citation(s) 27383793
Submission date Apr 21, 2014
Last update date May 15, 2019
Contact name Fatima Sanchez-Cabo
Phone +34 91 4531200
Organization name CNIC
Street address Melchor Fernandez Almagro
City Madrid
ZIP/Postal code 28029
Country Spain
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (24)
GSM1371842 BL/6J:C57 Liver mix1
GSM1371843 BL/6J:C57 Liver mix2
GSM1371844 BL/6J:C57 Liver mix3
BioProject PRJNA245010
SRA SRP041313

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Supplementary file Size Download File type/resource
GSE56933_matrix_table.txt.gz 1.7 Mb (ftp)(http) TXT
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