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| Status |
Public on Apr 01, 2015 |
| Title |
IL-17 mediates susceptibility to breast cancer growth by promoting the recruitment of tumorigenic neutrophils |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The aggressiveness of invasive ductal carcinoma (IDC) of the breast is associated with increased IL-17 levels. In this study, we investigated the role of IL-17 in invasive breast tumor pathogenesis. We found that metastatic tumor-infiltrating T lymphocytes produced elevated levels of IL-17, whereas IL-17 neutralization inhibited tumor growth and prevented the migration of neutrophils and tumor cells to secondary disease sites. Tumorigenic neutrophils promote disease progression, and their depletion suppressed tumor growth. Moreover, IL-17 induced IL-6 and CXCL1 production in tumor cells, and IL-6 depletion reduced metastatic tumor growth and infiltration by Th17 cells and neutrophils. In addition, inoculation of a non-metastatic mammary tumor cell line pre-incubated with IL-17 promoted tumor growth, confirming the pro-tumor role of IL-17. Furthermore, high IL-17 expression was associated with lower disease-free survival (DFS) and worse prognosis in IDC patients. Thus, IL-17 blockade represents an attractive approach for the control of invasive breast tumors.
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| |
|
| Overall design |
Biopsies of patients with breast tumors
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| |
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| Contributor(s) |
De Carvalho D, Benevides L |
| Citation missing |
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| Submission date |
Apr 15, 2014 |
| Last update date |
Mar 20, 2017 |
| Contact name |
Daniel De Carvalho |
| E-mail(s) |
ddecarv@uhnresearch.ca
|
| Organization name |
Ontario Cancer Institute
|
| Street address |
101 College Street, room 9-302
|
| City |
Toronto |
| State/province |
ON |
| ZIP/Postal code |
M5G 1L7 |
| Country |
Canada |
| |
|
| Platforms (1) |
| GPL6883 |
Illumina HumanRef-8 v3.0 expression beadchip |
|
| Samples (16)
|
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| Relations |
| BioProject |
PRJNA244683 |
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