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Series GSE56717 Query DataSets for GSE56717
Status Public on Jun 10, 2014
Title Expression data from human metastatic melanoma cell lines
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The genetic changes underlying metastatic melanoma need to be deciphered to develop new and effective therapeutics. Previously, genome-wide microarray analyses of human melanoma identified two reciprocal gene expression programs, that included expression of mRNAs regulated by either transforming growth factor, beta 1 (TGFB1) pathways or microphthalmia-associated transcription factor (MITF)/SRY-box containing gene 10 (SOX10) pathways. We extend this knowledge to include gene expression analyses of 5 additional human melanoma lines, and show that these lines also fall into either TGFB1 or MITF/SOX10 gene expression groups.
These mRNA expression studies were followed up by miRNA expression analyses.
Overall design Microarray analyses were performed on 5 metastatic melanoma lines in 3 replicates. Standard Affymetrix protocols were used.
Contributor(s) Hwang H, Baxter LL, Loftus SK, Cronin JC, Trivedi NS, Borate B, Pavan WJ
Citation(s) 24767210
Submission date Apr 10, 2014
Last update date Dec 06, 2018
Contact name Laura L Baxter
Organization name NIH
Department NHGRI
Street address 49 Convent Drive
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (15)
GSM1367259 Melanoma cell line 0380MMU_rep1
GSM1367260 Melanoma cell line 0380MMU_rep2
GSM1367261 Melanoma cell line 0380MMU_rep3
BioProject PRJNA244359

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56717_RAW.tar 31.4 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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