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Series GSE56614 Query DataSets for GSE56614
Status Public on Apr 10, 2014
Title Different miRNA expression profiles between human breast cancer turmors and serum
Organism Homo sapiens
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary We identified total 174 significantly differentially expressed miRNAs between tumors and the normal tissues, and 109 miRNAs between serum from patients and serum from healthy individuals. There are only 10 common miRNAs. This suggests that only a small portion of tumor miRNAs are released into serum selectively. Interestingly, the expression change pattern of 28 miRNAs is opposite between breast cancer tumors and serum. Functional analysis shows that the differentially expressed miRNAs and their target genes form a complex interaction network affecting many biological processes and involving in cancer-related pathways such as prostate, basal cell carcinoma, acute myeloid leukymia, and more.
Overall design A bunch of miRNAs have been demonstrated to be aberrantly expressed in cancer tumor tissue and serum. The miRNA signatures identified from the serum samples could serve as potential noninvasive diagnostic markers for breast cancer. The roles of the miRNAs in cancerigenesis is unclear. In this study, we generated the expression profiles of miRNAs from the paired breast cancer tumors, normal, tissue, and serum samples from eight patients using small RNA-sequencing. Serum samples from eight healthy individuals were used as normal controls.
Contributor(s) Zhu J, Zheng Z, Wang J, Sun J, Wang P, Cheng X, Fu L, Zhang L, Wang Z, Li Z
Citation(s) 24904649
Submission date Apr 08, 2014
Last update date May 15, 2019
Contact name ZhaoYun Li
Organization name Wenzhou Medical University
Department School of Laboratory Medicine and Life Science
Street address Chashan Higher Education Park
City Wenzhou
State/province Zhejiang province
ZIP/Postal code 318000
Country China
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (4)
GSM1365849 Tumor_serum
GSM1365850 Tumor_tissue
GSM1365851 Normal_serum
BioProject PRJNA244080
SRA SRP041033

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Supplementary file Size Download File type/resource
GSE56614_RAW.tar 30.0 Kb (http)(custom) TAR (of TXT)
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Raw data are available in SRA
Processed data provided as supplementary file

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