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Series GSE56601 Query DataSets for GSE56601
Status Public on Feb 23, 2015
Title WGBS data of pediatric B-cell acute leukemias
Organism Homo sapiens
Experiment type Methylation profiling by high throughput sequencing
Summary We investigated DNA methylomes of 227 pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles.
The current study identified a link between DNA methylome of B-cell acute lymphoblastic leukemias (B-ALLs) and embryonic stem cell (ESC) bivalency, through which tumor cells can mimic the pluripotency of ESCs.
Overall design A total of 231 pediatric patients with B-ALL were utilized from the California Childhood Cancer Study. After informed consent, bone marrow specimens packed with leukemic blasts were obtained in each patient. Expression and methylation data of purified Pre-B cells in four developmental stages were retrieved from our previous study (Lee et al., Nucleic Acids Res 2012).
Contributor(s) Lee S, Wiemels JL
Citation(s) 25690899
Submission date Apr 08, 2014
Last update date May 15, 2019
Contact name Seung-Tae Lee
Phone +82-10-9933-5465
Organization name UCSF
Street address 1450 3rd Street
City San Francisco
State/province CA
ZIP/Postal code 94158
Country USA
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (2)
GSM1365547 B-ALL, ETV6/RUNX1
GSM1365548 B-ALL, hyperdiploid
This SubSeries is part of SuperSeries:
GSE56602 Two-Track Epigenetic Remodeling and Backtracking to Embryonic Stem Cell Bivalency in B-cell Acute Lymphoblastic Leukemias
BioProject PRJNA244061
SRA SRP041025

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Supplementary file Size Download File type/resource
GSE56601_WGBS_processed_data.txt.gz 322.3 Mb (ftp)(http) TXT
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Processed data are available on Series record

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