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Series GSE56600 Query DataSets for GSE56600
Status Public on Feb 23, 2015
Title Methylation data of pediatric B-cell acute leukemias
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary We investigated DNA methylomes of 227 pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles.
The current study identified a link between DNA methylome of B-cell acute lymphoblastic leukemias (B-ALLs) and embryonic stem cell (ESC) bivalency, through which tumor cells can mimic the pluripotency of ESCs.
Overall design A total of 231 pediatric patients with B-ALL were utilized from the California Childhood Cancer Study. After informed consent, bone marrow specimens packed with leukemic blasts were obtained in each patient. Expression and methylation data of purified Pre-B cells in four developmental stages were retrieved from our previous study (Lee et al., Nucleic Acids Res 2012).
Contributor(s) Lee S, Wiemels JL
Citation(s) 25690899
Submission date Apr 08, 2014
Last update date Mar 22, 2019
Contact name Seung-Tae Lee
Phone +82-10-9933-5465
Organization name UCSF
Street address 1450 3rd Street
City San Francisco
State/province CA
ZIP/Postal code 94158
Country USA
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (227)
GSM1365320 0121C
GSM1365321 0419C
GSM1365322 0544C
This SubSeries is part of SuperSeries:
GSE56602 Two-Track Epigenetic Remodeling and Backtracking to Embryonic Stem Cell Bivalency in B-cell Acute Lymphoblastic Leukemias
BioProject PRJNA244063

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56600_Non-normalized_Illumina_methylation_data.txt.gz 518.3 Mb (ftp)(http) TXT
GSE56600_Normalized_Illumina_methylation_data.txt.gz 445.7 Mb (ftp)(http) TXT
GSE56600_RAW.tar 183.1 Mb (http)(custom) TAR
Processed data are available on Series record

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