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Series GSE56599 Query DataSets for GSE56599
Status Public on Feb 23, 2015
Title Expression data of pediatric B-cell acute leukemias
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We investigated DNA methylomes of 227 pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles.
The current study identified a link between DNA methylome of B-cell acute lymphoblastic leukemias (B-ALLs) and embryonic stem cell (ESC) bivalency, through which tumor cells can mimic the pluripotency of ESCs.
Overall design A total of 231 pediatric patients with B-ALL were utilized from the California Childhood Cancer Study. After informed consent, bone marrow specimens packed with leukemic blasts were obtained in each patient. Expression and methylation data of purified Pre-B cells in four developmental stages were retrieved from our previous study (Lee et al., Nucleic Acids Res 2012).
Contributor(s) Lee S, Wiemels JL
Citation(s) 25690899
Submission date Apr 08, 2014
Last update date Jul 26, 2018
Contact name Seung-Tae Lee
Phone +82-10-9933-5465
Organization name UCSF
Street address 1450 3rd Street
City San Francisco
State/province CA
ZIP/Postal code 94158
Country USA
Platforms (1)
GPL6244 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Samples (81)
GSM1365239 0544C
GSM1365240 0166C
GSM1365241 0376C
This SubSeries is part of SuperSeries:
GSE56602 Two-Track Epigenetic Remodeling and Backtracking to Embryonic Stem Cell Bivalency in B-cell Acute Lymphoblastic Leukemias
BioProject PRJNA244060

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56599_RAW.tar 334.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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