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Series GSE56588 Query DataSets for GSE56588
Status Public on Feb 13, 2015
Title A Methylation-Based Signature Predicts Survival In Hepatocellular Carcinoma Patient
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Epigenetic deregulation is a critical event in human malignancies. A number of DNA methylation markers are currently under evaluation as diagnostic and prognostic biomarkers for many cancers. However, its potential role in hepatocellular carcinoma (HCC) is under-explored. Aims: To develop a DNA methylation-based prognostic signature in surgically resected HCC
Overall design Tumors from 224 HCC resected patients, 10 normal Liver individuals and 9 Cirrhotic patients were analyzed. Methylome profiling was done with Illumina HumanMethylation450 (485,000 CpG, 96% of known CpG islands). We selected probes in CpG islands located in promoters, hypermethylated (B value higher than 50%) in at least 5% of the tumors and hypomethylated (B value lower than 33%) in more than 90% of normal liver.
Contributor(s) Portela A, Esteller M, Villanueva A, Llovet J
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Submission date Apr 08, 2014
Last update date Mar 22, 2019
Contact name Manel Esteller
Organization name IDIBELL
Department PEBC
Lab Cancer Epigenetics
Street address Hospital Duran i Reynals Av. Gran Via s/n km, 2.7
City L'Hospitalet de Llobregat
State/province Barcelona
ZIP/Postal code 08908
Country Spain
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (243)
GSM1364809 B43
GSM1364810 B44
GSM1364811 B46
BioProject PRJNA244008

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56588_Heptromics_avrg_beta.txt.gz 948.3 Mb (ftp)(http) TXT
GSE56588_Heptromics_raw_signal_intensities.txt.gz 1.9 Gb (ftp)(http) TXT
GSE56588_RAW.tar 183.1 Mb (http)(custom) TAR
Processed data are available on Series record

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