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| Status |
Public on Sep 22, 2015 |
| Title |
DNA methylation landscapes of human fetal development |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
Here we assessed the genome-scale DNA methylation of 472,703 autosomal CpG sites in 4 tissues (muscle, amnion, pancreas and adrenal glands) on 3 time-points (9, 18 and 22 weeks) using the Illumina 450k array. We identified 52,134 CpG sites with dynamic DNA methylation during fetal development (gain or loss >20% from 9 to 22 weeks), where the period between 9 and 18 weeks was most dynamic. Loss in DNA methylation (25,579 CpGs), displayed clear tissue-specific patterns near genes enriched for a role in tissue-specific processes. Gain in DNA methylation (26,555 CpGs) occurred often near genes involved in (tissue-specific) developmental processes.
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| Overall design |
Comparison of DNA methylation of four fetal human tissues on three time points of gestation: 9, 18 and 22 weeks of gestation.
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| Contributor(s) |
Slieker RC, Roost MS, van Iperen L, Suchiman HE, Tobi EW, Carlotti F, de Koning EP, Slagboom PE, Heijmans BT, Chuva de Sousa Lopes SM |
| Citation(s) |
26492326 |
| Submission date |
Apr 04, 2014 |
| Last update date |
Mar 22, 2019 |
| Contact name |
Roderick Slieker |
| E-mail(s) |
r.c.slieker@lumc.nl
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| Organization name |
Leiden University Medical Center
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| Department |
Molecular Cell Biology
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| Street address |
PO Box 9600
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| City |
Leiden |
| ZIP/Postal code |
2333RC |
| Country |
Netherlands |
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| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
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| Samples (34)
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| Relations |
| BioProject |
PRJNA243583 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE56515_RAW.tar |
183.1 Mb |
(http)(custom) |
TAR |
| GSE56515_raw_signal_intensities.txt.gz |
78.7 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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