GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE56515 Query DataSets for GSE56515
Status Public on Sep 22, 2015
Title DNA methylation landscapes of human fetal development
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Here we assessed the genome-scale DNA methylation of 472,703 autosomal CpG sites in 4 tissues (muscle, amnion, pancreas and adrenal glands) on 3 time-points (9, 18 and 22 weeks) using the Illumina 450k array. We identified 52,134 CpG sites with dynamic DNA methylation during fetal development (gain or loss >20% from 9 to 22 weeks), where the period between 9 and 18 weeks was most dynamic. Loss in DNA methylation (25,579 CpGs), displayed clear tissue-specific patterns near genes enriched for a role in tissue-specific processes. Gain in DNA methylation (26,555 CpGs) occurred often near genes involved in (tissue-specific) developmental processes.
Overall design Comparison of DNA methylation of four fetal human tissues on three time points of gestation: 9, 18 and 22 weeks of gestation.
Contributor(s) Slieker RC, Roost MS, van Iperen L, Suchiman HE, Tobi EW, Carlotti F, de Koning EP, Slagboom PE, Heijmans BT, Chuva de Sousa Lopes SM
Citation(s) 26492326
Submission date Apr 04, 2014
Last update date Mar 22, 2019
Contact name Roderick Slieker
Organization name Leiden University Medical Center
Department Molecular Cell Biology
Street address PO Box 9600
City Leiden
ZIP/Postal code 2333RC
Country Netherlands
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (34)
GSM1363065 E101559_Amnion
GSM1363066 E101539.4_Amnion
GSM1363067 E101578.2_Amnion
BioProject PRJNA243583

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56515_RAW.tar 183.1 Mb (http)(custom) TAR
GSE56515_raw_signal_intensities.txt.gz 78.7 Mb (ftp)(http) TXT
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap