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Series GSE56386 Query DataSets for GSE56386
Status Public on Apr 01, 2014
Title Understanding molecular mechanisms of Cetuximab insensitivity in Colorectal Cancer (CRC)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Mutational status of KRAS in CRC is used to aid patient stratification for Cetuximab treatment. However, only a subset (10-40%) of patients with wt KRAS respond. We analyzed 40 mCRC tumors for Cetuximab response using a functional ex vivo platform. In the subset of non-responsive tumors, mutational (KRAS/BRAF and PIK3CA) and expression (AREG/EREG) analysis of key genes, transcriptomic profiling and GSEA were carried out to elucidate the molecular mechanisms underlying the response. Our analysis revealed deregulation of multiple pathways, notably Notch and Erbb2 and combined blockade of these two nodes elicited significant antitumor response. These findings collectively indicate the dependence of Cetuximab insensitive mCRC tumors on Notch and Erbb2 for survival and progression.
Overall design 8 Primary tumors tested in ex vivo platform for response to Cetuximab were subjected to expression analysis
Contributor(s) Brijwani N
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Submission date Mar 31, 2014
Last update date Nov 27, 2018
Contact name Pradip K Majumder
Organization name Mitra Biotech Pvt Ltd.
Street address Suite 202, Narayana Nethralaya, Narayana Hrudayalaya Health City, Hosur Main Road, Bangalore 99, Karnataka State.
City Bangalore
ZIP/Postal code 560099
Country India
Platforms (1)
GPL13607 Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version)
Samples (8)
GSM1360149 Primary CRC tumor responder to Cetuximab in ex vivo platform 1
GSM1360150 Primary CRC tumor responder to Cetuximab in ex vivo platform 2
GSM1360151 Primary CRC tumor responder to Cetuximab in ex vivo platform 3
BioProject PRJNA243086

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56386_RAW.tar 30.0 Mb (http)(custom) TAR (of TXT)
GSE56386_normalized_by_gene.txt.gz 1.6 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data provided as supplementary file
Processed data are available on Series record

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