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Series GSE56316 Query DataSets for GSE56316
Status Public on Mar 28, 2014
Title Epigenetic regulation of MYC modulates glioblastoma tumorigenicity
Organism Homo sapiens
Experiment type SNP genotyping by SNP array
Summary One aspect of intra-tumoral heterogeneity in glioblastoma involves subpopulations of cells capable of self-renewal and indefinite propagation. Conceptually, this capacity is frequently treated as a static property. Here we provide data suggesting that tumorigenicity in glioblastomais a dynamic property that can be acquired or lost. Integrated expression analyses suggest that tumorigenicity is determined by the level of MYC expression relative to a threshold. Transitions between tumorigenic and non-tumorigenic cell states are associated with changes in histone modifications at the MYC locus, suggesting tumorigenicity is epigenetically regulated.
 
Overall design To verify genomic stability at the nucleotide level, we tested whether subclones derived from single cells shared common Single-Nucleotide Polymorphisms (SNPs). Ten single cell-derived subclones of U87MG underwent SNP profiling by Affymetrix Human Mapping 250K Nsp arrays.
 
Contributor(s) Harismendy O, C. Chen C, Matsui H, Li K
Citation(s) 26159421
Submission date Mar 27, 2014
Last update date May 17, 2017
Contact name Olivier Harismendy
E-mail(s) oharismendy@ucsd.edu
Organization name UC San Diego
Department Medicine / Moores Cancer Center
Lab Oncogenomics Laboratory
Street address 3855 Health Sciences Drive #0820
City La Jolla
State/province California
ZIP/Postal code 92093-0820
Country USA
 
Platforms (1)
GPL3718 [Mapping250K_Nsp] Affymetrix Mapping 250K Nsp SNP Array
Samples (10)
GSM1359061 U87MG-SC1
GSM1359062 U87MG-SC2
GSM1359063 U87MG-SC3
Relations
BioProject PRJNA242894

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56316_RAW.tar 257.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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