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| Status |
Public on Mar 29, 2014 |
| Title |
Integrated miRNA-mRNA analysis revealing the potential roles of miRNAs in chordomas |
| Platform organisms |
Homo sapiens; synthetic construct |
| Sample organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Non-coding RNA profiling by array
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| Summary |
Emerging evidence suggests that microRNAs (miRNAs) are crucially involved in tumorigenesis and that paired expression profiles of miRNAs and mRNAs can be used to identify functional miRNA-target relationships with high precision.However, no studies have applied integrated analysis to miRNA and mRNA profiles in chordomas.
The purpose of this study was to provide insights into the pathogenesis of chordomas by using this integrated analysis method
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| Overall design |
Differentially expressed miRNAs and mRNAs of chordomas (n = 3) and notochord tissues (n = 3) were analyzed by using microarrays with hierarchical clustering analysis. Subsequently, the target genes of the differentially expressed miRNAs were predicted and overlapped with the differentially expressed mRNAs. Then, GO and pathway analyses were performed for the intersecting genes
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| Contributor(s) |
Long C, Jiang L, Wei F, Ma C, Zhou H, Yang S, Liu X, Liu Z |
| Citation(s) |
23826111 |
| |
| Submission date |
Mar 25, 2014 |
| Last update date |
Feb 26, 2020 |
| Contact name |
zhongjun Liu |
| E-mail(s) |
starsky298@gmail.com
|
| Phone |
15281085496
|
| Organization name |
Peking University Third Hospital
|
| Department |
Department of Orthopedics
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| Lab |
Spine tumor center
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| Street address |
49 North Garden Rd, Haidian, 100191, Beijing, China.
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| City |
Beijing, China |
| State/province |
Beijing |
| ZIP/Postal code |
100191 |
| Country |
China |
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| Platforms (2) |
| GPL10739 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [probe set (exon) version] |
| GPL14613 |
[miRNA-2] Affymetrix Multispecies miRNA-2 Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA242940 |
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