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Series GSE56183 Query DataSets for GSE56183
Status Public on Mar 29, 2014
Title Integrated miRNA-mRNA analysis revealing the potential roles of miRNAs in chordomas
Platform organisms Homo sapiens; synthetic construct
Sample organism Homo sapiens
Experiment type Expression profiling by array
Non-coding RNA profiling by array
Summary Emerging evidence suggests that microRNAs (miRNAs) are crucially involved in tumorigenesis and that paired expression profiles of miRNAs and mRNAs can be used to identify functional miRNA-target relationships with high precision.However, no studies have applied integrated analysis to miRNA and mRNA profiles in chordomas.
The purpose of this study was to provide insights into the pathogenesis of chordomas by using this integrated analysis method
Overall design Differentially expressed miRNAs and mRNAs of chordomas (n = 3) and notochord tissues (n = 3) were analyzed by using microarrays with hierarchical clustering analysis. Subsequently, the target genes of the differentially expressed miRNAs were predicted and overlapped with the differentially expressed mRNAs. Then, GO and pathway analyses were performed for the intersecting genes
Contributor(s) Long C, Jiang L, Wei F, Ma C, Zhou H, Yang S, Liu X, Liu Z
Citation(s) 23826111
Submission date Mar 25, 2014
Last update date Feb 26, 2020
Contact name zhongjun Liu
Phone 15281085496
Organization name Peking University Third Hospital
Department Department of Orthopedics
Lab Spine tumor center
Street address 49 North Garden Rd, Haidian, 100191, Beijing, China.
City Beijing, China
State/province Beijing
ZIP/Postal code 100191
Country China
Platforms (2)
GPL10739 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [probe set (exon) version]
GPL14613 [miRNA-2] Affymetrix Multispecies miRNA-2 Array
Samples (12)
GSM1357324 chordoma_1 (mRNA)
GSM1357325 chordoam_2 (mRNA)
GSM1357326 chordoma_3 (mRNA)
BioProject PRJNA242940

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56183_RAW.tar 23.1 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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