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Series GSE55915 Query DataSets for GSE55915
Status Public on May 14, 2014
Title Gene Expression profiles of colon from Hif-1α+/+, Hif-1αLSL/LSL
Organism Mus musculus
Experiment type Expression profiling by array
Summary To investigate the detailed molecular mechanisms for the regulatory role of HIF-1α in colon, microarray gene expression analysis was performed on colon RNA isolated from 6- to 8-week-old Hif-1α+/+, Hif-1αLSL/LSL mice.
Background & Aims: The progression and growth of solid tumors leads to a state where tumors outgrow their capacity for efficient oxygenation and nutrient uptake and an increase in tumor hypoxia. Tumor hypoxic response is mediated by hypoxia-inducible factor (HIF)-1a and HIF-2a. These transcription factors regulate a battery of genes that are critical for tumor oxygenation, tumor metabolism, and cell proliferation and survival. Therefore, inhibitors of HIF have been sought for as anti-neoplastic agents in several different kinds of cancers. Interestingly, in ischemic and inflammatory diseases of the intestine, activation of HIF-1a is beneficial, and can reduce intestinal inflammation. The efficacy of pharmacological agents that chronically activate HIF-1a are decreased due to the tumorigenic potential of HIF. However, recent advance in understanding HIF signaling have identified mechanisms, which could allow for isoform specific activators. Activation of HIF-2a increases colon carcinogenesis and progression in mouse models. However, the role of chronic HIF-1a activation is unclear in the progression in colon cancer. The present data demonstrates that activation of HIF-1a in epithelial cells does not increase colon carcinogens or progression in two mouse models of colon cancer, and provides the proof of principle that HIF-1a activation maybe safe as therapies for inflammatory bowel disease.
 
Overall design Global gene expression profiling in colon RNAs isolated from 6- to 8-week-old Hif-1α+/+ (n=5, Shah 019) and Hif-1αLSL/LSL (n=5, Shah 020).
 
Contributor(s) Xue X, Shah Y
Citation(s) 24875099
Submission date Mar 14, 2014
Last update date Apr 18, 2017
Contact name XIANG XUE
E-mail(s) xxue@umich.edu
Phone 7346155041
Organization name Umich
Street address 1301 E. Catherine Street
City Ann Arbor
State/province Michigan
ZIP/Postal code 48109
Country USA
 
Platforms (1)
GPL11533 [MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version]
Samples (2)
GSM1348378 Hif-1α+/+
GSM1348379 Hif-1αLSL/LSL
Relations
BioProject PRJNA241309

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Supplementary file Size Download File type/resource
GSE55915_RAW.tar 8.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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