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Series GSE55915 Query DataSets for GSE55915
Status Public on May 14, 2014
Title Gene Expression profiles of colon from Hif-1α+/+, Hif-1αLSL/LSL
Organism Mus musculus
Experiment type Expression profiling by array
Summary To investigate the detailed molecular mechanisms for the regulatory role of HIF-1α in colon, microarray gene expression analysis was performed on colon RNA isolated from 6- to 8-week-old Hif-1α+/+, Hif-1αLSL/LSL mice.
Background & Aims: The progression and growth of solid tumors leads to a state where tumors outgrow their capacity for efficient oxygenation and nutrient uptake and an increase in tumor hypoxia. Tumor hypoxic response is mediated by hypoxia-inducible factor (HIF)-1a and HIF-2a. These transcription factors regulate a battery of genes that are critical for tumor oxygenation, tumor metabolism, and cell proliferation and survival. Therefore, inhibitors of HIF have been sought for as anti-neoplastic agents in several different kinds of cancers. Interestingly, in ischemic and inflammatory diseases of the intestine, activation of HIF-1a is beneficial, and can reduce intestinal inflammation. The efficacy of pharmacological agents that chronically activate HIF-1a are decreased due to the tumorigenic potential of HIF. However, recent advance in understanding HIF signaling have identified mechanisms, which could allow for isoform specific activators. Activation of HIF-2a increases colon carcinogenesis and progression in mouse models. However, the role of chronic HIF-1a activation is unclear in the progression in colon cancer. The present data demonstrates that activation of HIF-1a in epithelial cells does not increase colon carcinogens or progression in two mouse models of colon cancer, and provides the proof of principle that HIF-1a activation maybe safe as therapies for inflammatory bowel disease.
Overall design Global gene expression profiling in colon RNAs isolated from 6- to 8-week-old Hif-1α+/+ (n=5, Shah 019) and Hif-1αLSL/LSL (n=5, Shah 020).
Contributor(s) Xue X, Shah Y
Citation(s) 24875099
Submission date Mar 14, 2014
Last update date Apr 18, 2017
Contact name XIANG XUE
Phone 7346155041
Organization name Umich
Street address 1301 E. Catherine Street
City Ann Arbor
State/province Michigan
ZIP/Postal code 48109
Country USA
Platforms (1)
GPL11533 [MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version]
Samples (2)
GSM1348378 Hif-1α+/+
GSM1348379 Hif-1αLSL/LSL
BioProject PRJNA241309

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Supplementary file Size Download File type/resource
GSE55915_RAW.tar 8.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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