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Series GSE55754 Query DataSets for GSE55754
Status Public on Feb 14, 2017
Title Bmi1 defines long-term adult cardiac stem cells in heart homeostasis and repair
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We have found the existence of a Bmi1+ population in the adult heart contributing to the organ low-rate turnover and repair with the generation of new cardiomyocytes. We show that the Bmi1+ population is a sub-population of the cardiac Sca-1+ progenitor cells. We have analyzed the gene profile by deep-sequencing (RNA-Seq) of Bmi1+ and Sca-1+Bmi1- cells in homeostatic heart condition. On the other hand, we have compared gene profile by deep-sequencing (RNA-Seq) of Bmi1+ cells in homeostatic condition versus Bmi1+ cells 5 days after myocardial infarction (MI). Analysis of RNA-Seq data revealed a differential expression signature between both subsets of cardiac stem/progenitors cells in homeostatic condition and also differences between Bmi1+ cells after AMI versus homeostatic condition.
Overall design Examination of gene profile of 2 different cardiac stem /progenitors subsets (Bmi1+ and Sca-1+Bmi1-) co-existing inthe adult heart under steady state. Examination of gene profile of Bmi1+ cardiac stem cells in homeostatic condition versus MI
Contributor(s) Bernad A
Citation(s) 27472922, 30851670
Submission date Mar 10, 2014
Last update date May 15, 2019
Contact name Antonio Bernad
Organization name Spanish Cardiovascular Research Center
Street address Melchor Fernandez Almagro, 3
City Madrid
ZIP/Postal code 28029
Country Spain
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (12)
BioProject PRJNA240889
SRA SRP039628

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Supplementary file Size Download File type/resource
GSE55754_matrix_table_MI.xls.gz 1.4 Mb (ftp)(http) XLS
GSE55754_matrix_table_homeostasis.xls.gz 1.4 Mb (ftp)(http) XLS
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