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Series GSE55258 Query DataSets for GSE55258
Status Public on Feb 22, 2014
Title Th17, Th22 and Treg cells are enriched in the healthy human cecum
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Dysregulation of CD4+ T cell populations leads to intestinal inflammation, but the regional differences of these T cell populations remained unclear in the healthy population. We first used flow cytometry to show that Th17 and Th22 cells are specifically enriched in the human cecum, while Th1 and Th2 cells do not differ regionally. We subsequently performed transcriptional profiling and found that Th17 was positively associated with the expression of RETN and negatively associated with TFF1, suggesting that the differential enrichment of Th17 cells in the healthy human cecum was underlined by the metabolic differences in this environment.
Overall design Transcriptional profiling with microarray on human intestinal pinch biopsies obtained from different sites of the healthy colon.
Contributor(s) Wolff MJ, Leung JM, Davenport M, Poles MA, Cho I, Loke P
Citation(s) 22829946
Submission date Feb 21, 2014
Last update date Nov 27, 2018
Contact name Mei San Tang
Organization name Washington University in St Louis
Department Pathology & Immunology
Street address 660 S Euclid, Campus Box 8118
City Saint Louis
State/province MO
ZIP/Postal code 63108
Country USA
Platforms (1)
GPL13607 Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version)
Samples (21)
GSM1332729 terminal_ileum_patient9
GSM1332730 ileocecal_valve_patient9
GSM1332731 appendiceal_orifice_patient9
BioProject PRJNA239009

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE55258_RAW.tar 70.7 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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