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Series GSE54570 Query DataSets for GSE54570
Status Public on May 16, 2014
Title Expression data from human brain dorsolateral prefrontal cortex - including control samples and samples with major depression disorders (26 samples NY_BA9)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related information, but heterogeneity and various sources of noise have limited the discovery of disease mechanisms. As systematic dataset integration is becoming essential, we developed methods and performed meta-clustering of gene coexpression links in 11 transcriptome studies from postmortem brains of human subjects with major depressive disorder (MDD) and non-psychiatric control subjects. We next sought enrichment in the top 50 meta-analyzed coexpression modules for genes otherwise identified by GWAS for various sets of disorders. One coexpression module of 88 genes was consistently and significantly associated with GWAS for MDD, other neuropsychiatric disorders and brain functions, and for medical illnesses with elevated clinical risk of depression, but not for other diseases (See publication for details).
Overall design 26 total samples in 13 pairs were analyzed in postmortem tissue from the dorsolateral prefrontal cortex.
Contributor(s) Sibille E
Citation(s) 24608543
Submission date Jan 30, 2014
Last update date Aug 10, 2018
Contact name Etienne Sibille
Phone 412-624-0804
Organization name University of Pittsburgh
Department Psychiatry
Street address 450 Technology Drive, Suite 231
City Pittsburgh
State/province PA
ZIP/Postal code 15219
Country USA
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (26)
GSM1319116 Control matched sample pair brain dorsolateral prefrontal cortex NY_BA9 #1
GSM1319117 Control matched sample pair brain dorsolateral prefrontal cortex NY_BA9 #2
GSM1319118 Control matched sample pair brain dorsolateral prefrontal cortex NY_BA9 #3
BioProject PRJNA237163

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Supplementary file Size Download File type/resource
GSE54570_RAW.tar 91.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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