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Series GSE54415 Query DataSets for GSE54415
Status Public on Jan 28, 2014
Title Genome-Scale Profiling of DNA Methylation in Sporadic Pituitary Macroadenomas: Association with Tumor Invasion and Histopathological Subtype
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary The pathophysiologic mechanisms driving tumorigenesis and invasion of sporadic pituitary macroadenomas (PAs) remain unknown. We hypothesized that alterations in DNA methylation are associated with PA invasion and histopathology subtype, and that genome-scale methylation analysis may complement current classification methods for sporadic PAs.
Overall design Twenty-four surgically-resected sporadic PAs with varying histopathological subtypes were assigned dichotomized Knosp invasion scores and examined using genome-wide DNA methylation patterns and RNA sequencing.
Contributor(s) Ling C, Pease M, Shi L, Punj V, Shiroishi MS, Commins D, Weisenberger DJ, Wang K, Zada G
Citation(s) 24781529
Submission date Jan 27, 2014
Last update date Mar 22, 2019
Contact name Chao Ling
Organization name University of Southern California
Department Zilkha Neurogenetic Institute
Lab Translational Neuroscience
Street address 1501 San Pablo street
City Los Angeles
State/province California
ZIP/Postal code 90089
Country USA
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (24)
GSM1314684 genomic DNA from pituitary macroadenoma Sample 1
GSM1314685 genomic DNA from pituitary macroadenoma Sample 2
GSM1314686 genomic DNA from pituitary macroadenoma Sample 3
BioProject PRJNA236458

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Supplementary file Size Download File type/resource
GSE54415_RAW.tar 183.1 Mb (http)(custom) TAR
GSE54415_readme.txt 2.2 Kb (ftp)(http) TXT
GSE54415_signal_intensities.txt.gz 137.4 Mb (ftp)(http) TXT
Processed data included within Sample table

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