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Series GSE54222 Query DataSets for GSE54222
Status Public on Jan 21, 2014
Title Hypermethylation in the ZBTB20 gene is associated with major depressive disorder
Organism Homo sapiens
Experiment type Methylation profiling by high throughput sequencing
Summary Genome-wide MeDIP-Sequencing was carried out on a total of 50 monozygotic twin pairs from the UK and Australia that are discordant for depression. We show that major depressive disorder is associated with significant hypermethylation within the coding region of ZBTB20, and is replicated in an independent cohort of 356 unrelated case-control individuals. The twins with major depressive disorder also show increased global variation in methylation in comparison with their unaffected co-twins. ZBTB20 plays an essential role in the specification of the Cornu Ammonis-1 field identity in the developing hippocampus, a region previously implicated in the development of major depressive disorder.
Overall design Epigenetic study of MZ twins discordant for Major Depressive Disorder
Contributor(s) Bell JT, Davies MN
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Submission date Jan 20, 2014
Last update date May 15, 2019
Contact name Matthew N Davies
Organization name King's College London
Department Twin Research
Lab Twin Research
Street address St Thomas' Hospital Campus
City London
State/province Greater London
ZIP/Postal code SE1 7EH
Country United Kingdom
Platforms (1)
GPL9052 Illumina Genome Analyzer (Homo sapiens)
Samples (54)
GSM1310414 MeDIP-seq data_18837
GSM1310415 MeDIP-seq data_18838
GSM1310416 MeDIP-seq data_21680
BioProject PRJNA235960
SRA SRP035541

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE54222_RAW.tar 4.1 Gb (http)(custom) TAR (of RPKM)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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