|
| Status |
Public on Mar 27, 2014 |
| Title |
The Menin–Bach2 axis is critical for regulating CD4 T cell senescence and homeostasis |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Although CD4 T cell senescence plays an important role in immunosenescence, the mechanisms remain unclear. We found that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, accompanied by the senescence-associated secretory phenotype (SASP) after antigenic stimulation. TH1 and TH2 differentiation was dysregulated in Menin-knockout CD4 T cells. Bach2, which regulates SASP and TH differentiation, was identified as a Menin target. Menin binds to the Bach2 locus, and controls its expression through maintenance of histone acetylation. These findings reveal a critical role of the Menin-Bach2 pathway in regulating CD4 T cell senescence and homeostasis, thus indicating the involvement of this pathway in the inhibition of age-associated development of inflammatory diseases, which are induced by immunosenescence.
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| |
|
| Overall design |
Examination of transcriptional factor Menin binding and histone modefications in Menin WT and KO CD4 T cells
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| |
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| Contributor(s) |
Kuwahara M, Yamashita M |
| Citation(s) |
24694524 |
| Submission date |
Jan 06, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Junpei Suzuki |
| Organization name |
Ehime University
|
| Department |
Graduate School of Medicine
|
| Lab |
Immunology
|
| Street address |
Shitukawa
|
| City |
Toon |
| ZIP/Postal code |
791-0295 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA233485 |
| SRA |
SRP034942 |
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