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Series GSE53831 Query DataSets for GSE53831
Status Public on Mar 27, 2014
Title The Menin–Bach2 axis is critical for regulating CD4 T cell senescence and homeostasis
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Although CD4 T cell senescence plays an important role in immunosenescence, the mechanisms remain unclear. We found that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, accompanied by the senescence-associated secretory phenotype (SASP) after antigenic stimulation. TH1 and TH2 differentiation was dysregulated in Menin-knockout CD4 T cells. Bach2, which regulates SASP and TH differentiation, was identified as a Menin target. Menin binds to the Bach2 locus, and controls its expression through maintenance of histone acetylation. These findings reveal a critical role of the Menin-Bach2 pathway in regulating CD4 T cell senescence and homeostasis, thus indicating the involvement of this pathway in the inhibition of age-associated development of inflammatory diseases, which are induced by immunosenescence.
Overall design Examination of transcriptional factor Menin binding and histone modefications in Menin WT and KO CD4 T cells
Contributor(s) Kuwahara M, Yamashita M
Citation(s) 24694524
Submission date Jan 06, 2014
Last update date May 15, 2019
Contact name Junpei Suzuki
Organization name Ehime University
Department Graduate School of Medicine
Lab Immunology
Street address Shitukawa
City Toon
ZIP/Postal code 791-0295
Country Japan
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (8)
GSM1301741 Primary_Th_Menin_ChIP
GSM1301742 Secondary_Th_Menin_ChIP
GSM1301743 Menin_WT_Th_H3K4me3
BioProject PRJNA233485
SRA SRP034942

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE53831_RAW.tar 3.5 Gb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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