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| Status |
Public on Dec 27, 2013 |
| Title |
CD7 promotes extramedullary involvement of the B-cell acute lymphoblastic leukemia line Tanoue by enhancing integrin beta2-dependent cell adhesiveness |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The Tanoue expressing firefly-luciferase gene, Luc-Tanoue, was transplanted into non-obese diabetic/severe combined immunodeficient mice, and cells infiltrated in the brain were cultured ex vivo. This process was repeated 4 times to obtain the highly invasive line Luc-Tanoue-F4. Comparison of the global gene expression signatures of Luc-Tanoue-F4 and Luc-Tanoue indicated that the CD7 gene showed the largest increase in expression among EMI-related genes in Luc-Tanoue-F4.
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| Overall design |
Tanoue expressing firefly-luciferase gene, Luc-Tanoue, was transplanted into non-obese diabetic/severe combined immunodeficient mice, and cells infiltrated in the brain were cultured ex vivo. This process was repeated 4 times to obtain the highly invasive line Luc-Tanoue-F4.
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| Contributor(s) |
Kondoh T, Kuribayashi K, Tanaka M, Watanabe N |
| Citation missing |
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| Submission date |
Dec 26, 2013 |
| Last update date |
Nov 27, 2018 |
| Contact name |
takashi kondo |
| E-mail(s) |
tkondo@sapmed.ac.jp
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| Organization name |
Sapporo Medical University
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| Department |
Clinical Laboratory Medicine
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| Street address |
South-1, West-16, Chuo-ku
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| City |
Sapporo |
| State/province |
Hokkaido |
| ZIP/Postal code |
060-8543 |
| Country |
Japan |
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| Platforms (1) |
| GPL13607 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA232584 |
