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Series GSE53368 Query DataSets for GSE53368
Status Public on May 19, 2014
Title Copper Metabolism Domain-Containing 1 Represses Genes That Promote Inflammation and Protects Mice From Colitis and Colitis-Associated Cancer
Organism Mus musculus
Experiment type Expression profiling by array
Summary Background & Aims

Activation of the transcription factor nuclear factor-κB (NF-κB) has been associated with the development of inflammatory bowel disease (IBD). Copper metabolism MURR1 domain containing 1 (COMMD1), a regulator of various transport pathways, has been shown to limit NF-κB activation. We investigated the roles of COMMD1 in the pathogenesis of colitis in mice and IBD in human beings.
Overall design Bone marrow derived macrophages (BMDM) were isolated from two individual wildtype - and two Commd1 knockout mice. Cells from individual mice were splitted and were treated with LPS for 3h, 24h, or, were left untreated. The corresponding 12 cell samples were subjected to total RNA preparation and subsequently used for Single-Color-based Microarray Analysis (Agilent Technologies).
Contributor(s) Li H, Weber A, Kracht M, Heike S, van de Sluis B, Burstein E
Citation(s) 24727021
Submission date Dec 16, 2013
Last update date Nov 01, 2017
Contact name Oliver Dittrich-Breiholz
Organization name Medical School Hannover
Department Research Core Unit Genomics
Street address Carl-Neuberg-Str. 1
City Hannover
ZIP/Postal code 30625
Country Germany
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (12)
GSM1290187 BMDM(WT)_untreated_rep1
GSM1290188 BMDM(WT)_untreated_rep2
GSM1290189 BMDM(KO)_untreated_rep1
BioProject PRJNA231849

Download family Format
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE53368_RAW.tar 108.7 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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