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Series GSE53357 Query DataSets for GSE53357
Status Public on Mar 01, 2016
Title Genome-wide screening for ELF4-binding sites.
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary ELF4 (also known as MEF) is a member of the ETS family of transcriptional factors. While an oncogenic role has been demonstrated for ELF4 mainly in hematopoietic malignancies, its definitive function in human carcinogenesis is not clear yet. Here we demonstrate that a wide array of human tumors carry somatic, loss-of-function mutations in ELF4 for its transcriptional activity, and restoring its function exerts anti-proliferative effects. To further explore the tumor suppressive function of ELF4, its binding sites were searched among the human genome with the use of chromatin immunoprecipitation coupled with sequencing (ChIP-seq).
Overall design Examination of binding site for FLAG-immunoprecipitated mock, ELF4 (WT) and ELF4 (L211M) with each input sample as a control.
Contributor(s) Ando M, Ueno T, Mano H
Citation(s) 26921333
Submission date Dec 16, 2013
Last update date May 15, 2019
Contact name Mizuo Ando
Phone 03-3815-5411
Organization name The University of Tokyo
Department Otolaryngology-Head and Neck Surgery
Street address 7-3-1 Hongo
City Bunkyo-ku
State/province Tokyo
ZIP/Postal code 113-0033
Country Japan
Platforms (1)
GPL10999 Illumina Genome Analyzer IIx (Homo sapiens)
Samples (6)
GSM1290019 ChIP-4b_mock-input
GSM1290020 ChIP-4b_wild-input
GSM1290021 ChIP-4b_mutant-input
BioProject PRJNA231834
SRA SRP034521

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE53357_mock_qv30_E_0_peak.cod.gz 623.0 Kb (ftp)(http) COD
GSE53357_mutant_qv30_E_0_peak.cod.gz 281.4 Kb (ftp)(http) COD
GSE53357_wild_qv30_E_0_peak.cod.gz 1.1 Mb (ftp)(http) COD
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Processed data are available on Series record
Raw data are available in SRA

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