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Series GSE53191 Query DataSets for GSE53191
Status Public on Dec 11, 2013
Title DNA Methylation Signature of Childhood Chronic Physical Aggression in T Cells of Both Men and Women (Illumina)
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary High frequency of physical aggression is the central feature of severe conduct disorder and is associated with a wide range of social, mental and physical health problems. We have previously tested the hypothesis that differential DNA methylation signatures in peripheral T cells are associated with a chronic aggression trajectory in males. Despite the fact that sex differences appear to play a pivotal role in determining the development, magnitude and frequency of aggression, most of previous studies focused on males, so little is known about female chronic physical aggression. We therefore tested here whether or not there is a signature of physical aggression in female DNA methylation and, if there is, how it relates to the signature observed in males.
Overall design Genome-wide promoter methylation profiles of T cell DNA from adult males and females on a Chronic Physical Aggression (CPA) trajectory during childhood and adolescence were compared to adults on a normative physical aggression trajectories (NPA). Each sample was bisulphite converted gDNA pooled in equimolar amounts. Three different pools of genomic DNA were made per group: male CPA (2 or 3 different subjects per pool), male NPA (4 different subjects per pool), female CPA (2 different subjects per pool) and female NPA (4 or 5 different subjects per pool) . The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles of the 2 groups in both sex.
Contributor(s) Guillemin C, Provencal N, Suderman M, Cote SM, Vitaro F, Hallett M, Tremblay RE, Moshe S
Citation(s) 24475181
Submission date Dec 10, 2013
Last update date Jun 04, 2021
Contact name Moshe Szyf
Organization name McGill University
Department Pharmacology
Street address McIntyre Medical Building, 3655 Promenade Sir William Osler, Room 1309
City Montreal
State/province Quebec
ZIP/Postal code H3G 1Y6
Country Canada
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (12)
GSM1286176 female-NPA1 pool
GSM1286177 female-CPA1 pool
GSM1286178 male-NPA1 pool
This SubSeries is part of SuperSeries:
GSE53193 DNA Methylation Signature of Childhood Chronic Physical Aggression in T Cells of Both Men and Women
BioProject PRJNA231081

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE53191_RAW.tar 183.1 Mb (http)(custom) TAR
GSE53191_signal_intensities.csv.gz 30.2 Mb (ftp)(http) CSV
Processed data included within Sample table

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