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Series GSE52937 Query DataSets for GSE52937
Status Public on Mar 30, 2015
Title Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis
Organism Homo sapiens
Experiment type Expression profiling by array
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary The human helicase senataxin (SETX) has been linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here we identified a role for SETX in controlling the antiviral response. Cells that had undergone depletion of SETX and SETX-deficient cells derived from patients with AOA2 had higher expression of antiviral mediators in response to infection than did wild-type cells. Mechanistically, we propose a model whereby SETX attenuates the activity of RNA polymerase II (RNAPII) at genes stimulated after a virus is sensed and thus controls the magnitude of the host response to pathogens and the biogenesis of various RNA viruses (e.g., influenza A virus and West Nile virus). Our data indicate a potentially causal link among inborn errors in SETX, susceptibility to infection and the development of neurologic disorders.

This SuperSeries is composed of the SubSeries listed below.
Overall design Refer to individual Series
Citation(s) 25822250, 27127234
Submission date Dec 03, 2013
Last update date May 15, 2019
Contact name Ivan Marazzi
Organization name Icahn School of Medicine at Mount Sinai
Department Department of Microbiology
Street address 1468 Madison Avenue
City New York
ZIP/Postal code 10029
Country USA
Platforms (2)
GPL10558 Illumina HumanHT-12 V4.0 expression beadchip
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (58)
GSM1278303 Untransfected cells 0h rep 1 (SETX)
GSM1278304 Untransfected cells 0h rep 2 (SETX)
GSM1278305 Untransfected cells 0h rep 3 (SETX)
This SuperSeries is composed of the following SubSeries:
GSE52932 Analysis of global gene expression profiles of A549 cells treated with SETX siRNA upon Influenza A/PR/8/34(ΔNS1) Infection
GSE52933 Analysis of global gene expression profiles of A549 cells treated with SETX siRNA under basal conditions
GSE52935 SETX attenuates the antiviral innate immune response and controls viral biogenesis (GRO-Seq)
BioProject PRJNA230480

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE52937_RAW.tar 82.0 Mb (http)(custom) TAR (of BEDGRAPH)
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