GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE52285 Query DataSets for GSE52285
Status Public on May 13, 2015
Title A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Methylation profiling by high throughput sequencing
Summary Our data throw light upon the effect of WRN deficiency on gene expression and epigenomic modification, which indicates aging-associated changes from both genomic and epigenomic level.
Overall design It was compared between WRN+/+ and WRN-/- in hESCs and hMSCs that the gene expression landscapes and epigenetic modifications(H3K4me3, H3K27me3, H3K9me3 and 5-methylcytosine).
Contributor(s) Li J, Zhang W, Liu X, Liu G, Tang F
Citation(s) 25931448
Submission date Nov 12, 2013
Last update date May 15, 2019
Contact name Jingyi Li
Organization name Peking University
Street address Yiheyuan Road, No.5, Haidian District
City Beijing
ZIP/Postal code 100871
Country China
Platforms (2)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (22)
GSM1262388 RNA-seq_WT_hESC_rep1
GSM1262389 RNA-seq_WT_hESC_rep2
GSM1262390 RNA-seq_WRN-KO_hESC_rep1
BioProject PRJNA227344
SRA SRP032942

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE52285_RAW.tar 855.5 Mb (http)(custom) TAR (of BED, BEDGRAPH, TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap