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Series GSE52196 Query DataSets for GSE52196
Status Public on Nov 15, 2013
Title Kidney from controls and SDHD-ESR mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Several mechanisms have been proposed to account for Sdh-mutation-induced tumorigenesis, the most accepted of which is based on the constitutive expression of the hypoxia-inducible factor 1alpha (Hif1alpha) at normal oxygen tension, a theory referred to as pseudo-hypoxic drive. Other molecular processes, such as oxidative stress, apoptosis or chromatin remodeling have been also proposed to play a causative role. Nevertheless, the actual contribution of each of these mechanisms has not been definitively established. Moreover, the biological factors that determine the tissue-specificity of these tumors have not been identified. In this work, we made use of the inducible SDHD-ESR mouse, a conditional mutant in the SdhD gene, which encodes the small subunit of MCII, and that acts as a tumor suppressor gene in humans.
We performed microarray analysis of kidney in order to identify other early gene expression changes elicited by SdhD deletion.
Overall design 8 samples from heterozygous (+/-) and 8 samples from null mutants (SDHD-ESR), paired by two and hybrydized against a pool of 8 samples from homozygous wt (+/+) animals.
Contributor(s) Piruat JI
Citation(s) 24465590
Submission date Nov 07, 2013
Last update date Jan 19, 2018
Contact name Jose I Piruat
Phone +34 955923088
Organization name Institute of Biomedicine of Seville (IBIS)
Department Hematology
Lab 202
Street address Hospital Virgen del Rocio-Edif IBiS. Av. Manuel Siurot sn
City Seville
ZIP/Postal code 41013
Country Spain
Platforms (1)
GPL10333 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Feature Number version)
Samples (8)
GSM1261046 het (+/-) kidney replicate 1
GSM1261047 het (+/-) kidney replicate 2
GSM1261048 SDHD-ESR kidney replicate 1
This SubSeries is part of SuperSeries:
GSE52197 Gene expression in adrenal medulla and kidney of a conditional mutant mouse in the SdhD gene
BioProject PRJNA227144

Download family Format
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE52196_RAW.tar 60.8 Mb (http)(custom) TAR (of GPR)
Processed data included within Sample table

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