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Series GSE51679 Query DataSets for GSE51679
Status Public on Sep 10, 2015
Title ChIP-seq assays for H3K27ac
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary By using FACS-sorted MC1-ZE7 ES cells, we analyzed the genome-wide distribution of H3K27ac and DNA methylation in Zscan4 positive ES cells (Em+) and Zscan4 negative ES cells (Em-). H3K27 hyperacetylation and DNA demethylation were detected in heterochromatic regions of Em+ cells, but not Em- cells. These results suggested that the Zscan4 state takes "open" chromatin conformation in ES cells.
Overall design H3K27ac in Zscan4 positive and negative cells
Contributor(s) Akiyama T
Citation(s) 26324425
Submission date Oct 24, 2013
Last update date May 15, 2019
Contact name Minoru S.H. Ko
Phone 410-558-8359
Organization name NIH
Department National Institute on Aging
Lab Lab of Genetics
Street address 251 Bayview Blvd, Suite 100, 10C
City Baltimore
State/province MD
ZIP/Postal code 21224
Country USA
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (4)
GSM1250433 MC1-ZE7 cells (Em-) H3K27ac rep1
GSM1250434 MC1-ZE7 cells (Em-) H3K27ac rep2
GSM1250435 MC1-ZE7 cells (Em+ high fraction) H3K27ac rep1
This SubSeries is part of SuperSeries:
GSE51682 Zscan4 mediates transient remodeling and transcriptional burst of heterochromatin in mouse embryonic stem cells
BioProject PRJNA224548
SRA SRP031895

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE51679_RAW.tar 1.7 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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