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| Status |
Public on Jul 14, 2015 |
| Title |
Genome wide DNA methylation analysis of leukemia and reprogrammed leukemia cells |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
We apply cellular reprogramming to an induced pluripotent cell state to human cell lines and primary samples exhibiting Chronic Myoloid Leukemia (CML). Addtionally, we generated an inducible CML BCR-ABL transgenic mouse model. Biological replicates (duplicates) were available for all samples. DNA methylation profiles for all cells were generated using Reduced Representation Bisulfite Sequencing (RRBS).
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| Overall design |
DNA methylation profiling of human leukemia cell lines, primary cells, derived iPS cells as well as transgenic mouse models for CML in duplicates using RRBS.
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| Contributor(s) |
Amabile G, Müller F, Di Ruscio A, Ebralidze A, Wongphayak S, Bock C, Tenen D |
| Citation(s) |
25997600 |
| Submission date |
Aug 29, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Fabian Müller |
| Organization name |
Saarland University
|
| Street address |
Campus A 2.4
|
| City |
Saarbrücken |
| ZIP/Postal code |
66123 |
| Country |
Germany |
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| Platforms (2) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
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| Samples (27)
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| Relations |
| BioProject |
PRJNA217518 |
| SRA |
SRP029339 |
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