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Series GSE50456 Query DataSets for GSE50456
Status Public on Jul 14, 2015
Title Genome wide DNA methylation analysis of leukemia and reprogrammed leukemia cells
Organisms Homo sapiens; Mus musculus
Experiment type Methylation profiling by high throughput sequencing
Summary We apply cellular reprogramming to an induced pluripotent cell state to human cell lines and primary samples exhibiting Chronic Myoloid Leukemia (CML). Addtionally, we generated an inducible CML BCR-ABL transgenic mouse model. Biological replicates (duplicates) were available for all samples. DNA methylation profiles for all cells were generated using Reduced Representation Bisulfite Sequencing (RRBS).
Overall design DNA methylation profiling of human leukemia cell lines, primary cells, derived iPS cells as well as transgenic mouse models for CML in duplicates using RRBS.
Contributor(s) Amabile G, Müller F, Di Ruscio A, Ebralidze A, Wongphayak S, Bock C, Tenen D
Citation(s) 25997600
Submission date Aug 29, 2013
Last update date May 15, 2019
Contact name Fabian Müller
Organization name Saarland University
Street address Campus A 2.4
City Saarbrücken
ZIP/Postal code 66123
Country Germany
Platforms (2)
GPL10999 Illumina Genome Analyzer IIx (Homo sapiens)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (27)
GSM1219533 CML_Gilli
GSM1219534 CML_GP
GSM1219535 CML-iPS_5_Passage_1
BioProject PRJNA217518
SRA SRP029339

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE50456_RAW.tar 428.5 Mb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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