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Series GSE50050 Query DataSets for GSE50050
Status Public on Dec 03, 2013
Title A Novel Gene Regulates Vesiculogenesis and Immunomodulation in Mycobacterium tuberculosis
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary After co-evolving with humans, its only major host, Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication, yet elicits enough immunopathology to ensure its transmission. Here, we provide evidence that this balance is regulated in part by a previously uncharacterized, cytosolic, membrane-associated protein with a novel structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity and quality of Mtb-derived membrane vesicles bearing TLR2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named virR (vesiculogenesis and immune response regulator). To our knowledge, VirR is the first bacterial protein identified to regulate vesiculogenesis.
Overall design Transcriptome sequencing of mouse macrophages uninfected, infected with WT Mtb, or infected with rv0431 mutant Mtb.
Contributor(s) Rath P, Elemento O, Nathan C
Citation(s) 24248369
Submission date Aug 20, 2013
Last update date May 15, 2019
Contact name Olivier Elemento
Street address 1305 York Avenue
City New York
State/province NY
ZIP/Postal code 10021
Country USA
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (8)
GSM1213153 Uninfected, rep 1
GSM1213154 Uninfected, rep 2
GSM1213155 WT Mtb-infected, rep 1
BioProject PRJNA215865
SRA SRP028938

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE50050_RAW.tar 1.3 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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