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Series GSE49576 Query DataSets for GSE49576
Status Public on Sep 02, 2014
Title Methylation data from medulloblastoma tumor samples
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large cohort of SHH-MBs across all age groups by sequencing, DNA methylation and expression profiling. Our data show that most adults but only half of the pediatric patients with SHH-MB will respond to SMO inhibition as predicted by molecular analysis of the primary tumor and tested in the SHH-xenografts, demonstrating that the next generation of SMO-inhibitor trials should be based on these predictive biomarkers.
To further dissect the biological differences between the different age groups within SHH medulloblastomas, we looked at the DNA methylation profiles of SHH medulloblastoma samples.
Overall design We investigated the DNA methylation profiles of 83 SHH medulloblastomas across all age groups using the Illumina 450k methylation array.
Contributor(s) Kool M, Pfister SM
Citation(s) 24651015
Submission date Aug 06, 2013
Last update date Mar 22, 2019
Contact name Marcel Kool
Organization name German Cancer Research Center DKFZ
Department Pediatric Neurooncology
Street address Im Neuenheimer Feld 280
City Heidelberg
ZIP/Postal code 69120
Country Germany
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (83)
GSM1262262 1m12
GSM1262263 1m31
GSM1262264 1m5
BioProject PRJNA214321

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE49576_RAW.tar 183.1 Mb (http)(custom) TAR
GSE49576_non-normalized.txt.gz 669.4 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record

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