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Series GSE49377 Query DataSets for GSE49377
Status Public on Sep 02, 2014
Title Methylation profiling data from medulloblastoma tumor samples
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large cohort of SHH-MBs across all age groups by sequencing, DNA methylation and expression profiling. Our data show that most adults but only half of the pediatric patients with SHH-MB will respond to SMO inhibition as predicted by molecular analysis of the primary tumor and tested in the SHH-xenografts, demonstrating that the next generation of SMO-inhibitor trials should be based on these predictive biomarkers.
To further dissect the biological differences between the different age groups within SHH medulloblastomas, we looked at the DNA methylation profiles of SHH medulloblastoma samples.
Overall design We investigated the DNA methylation profiles of 46 SHH medulloblastomas across all age groups using the Illumina 450k methylation array.
Contributor(s) Remke M, Cavalli FM, Hovestadt V, Kool M, Pfister SM, Taylor MD
Citation(s) 24651015
Submission date Jul 30, 2013
Last update date Mar 22, 2019
Contact name Marc Remke
Organization name The Hospital for Sick Children
Department Laboratory Medicine and Pathobiology
Street address 555 University Ave. Rm 1504
City Toronto
ZIP/Postal code M5G 1X8
Country Canada
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (46)
GSM1198400 MDT-MB-842
GSM1198401 MDT-MB-10
GSM1198402 MDT-MB-1333
BioProject PRJNA213744

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE49377_MB-SHH_MDT_450k_GEOupload_Raw.txt.gz 371.0 Mb (ftp)(http) TXT
GSE49377_RAW.tar 183.1 Mb (http)(custom) TAR
Processed data included within Sample table

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