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Series GSE49124 Query DataSets for GSE49124
Status Public on Mar 01, 2014
Title Expression data from JQ1 (0.2 uM) treated tamoxifen-resistant MCF7 cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Estrogen signaling pathway is critical for breast cancer development and has remained the major adjuvant therapeutic target for this disease. Tamoxifen has been used in clinic for many years to treat ER-positive breast cancer. However a great many (30%) suffer relapse due to drug resistance. In this study, the bromodomain inhibitor JQ1 was found to down-regulate ERalpha gene expression and have anti-tumor effect in cultured tamoxifen-resisant breast cancer cells.
We used microarrays to detail the global programme of gene expression in tamoxifen-resistant MCF7 cells treated with the bromodomain inhibitor JQ1.
Overall design Tamoxifen-resistant breast cancer MCF7 cells were treated with DMSO (vehicle) or JQ1 (0.2 uM) for 24 hours before total RNA was purified for microarray. Each sample was triplicated.
Contributor(s) Feng Q
Citation(s) 24874954
Submission date Jul 23, 2013
Last update date Jan 25, 2019
Contact name Qin Feng
Phone 8328428824
Organization name University of Houston
Department Biology and Biochemistry
Street address 3517 Cullen Blvd
City Houston
State/province TX
ZIP/Postal code 77204
Country USA
Platforms (1)
GPL10739 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [probe set (exon) version]
Samples (6)
GSM1194050 DMSO treatment, biological rep1
GSM1194051 DMSO treatment, biological rep2
GSM1194052 DMSO treatment, biological rep3
BioProject PRJNA213138

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE49124_RAW.tar 25.4 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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