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| Status |
Public on Mar 01, 2014 |
| Title |
Expression data from JQ1 (0.2 uM) treated tamoxifen-resistant MCF7 cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Estrogen signaling pathway is critical for breast cancer development and has remained the major adjuvant therapeutic target for this disease. Tamoxifen has been used in clinic for many years to treat ER-positive breast cancer. However a great many (30%) suffer relapse due to drug resistance. In this study, the bromodomain inhibitor JQ1 was found to down-regulate ERalpha gene expression and have anti-tumor effect in cultured tamoxifen-resisant breast cancer cells.
We used microarrays to detail the global programme of gene expression in tamoxifen-resistant MCF7 cells treated with the bromodomain inhibitor JQ1.
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| Overall design |
Tamoxifen-resistant breast cancer MCF7 cells were treated with DMSO (vehicle) or JQ1 (0.2 uM) for 24 hours before total RNA was purified for microarray. Each sample was triplicated.
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| Contributor(s) |
Feng Q |
| Citation(s) |
24874954 |
| |
| Submission date |
Jul 23, 2013 |
| Last update date |
Jan 25, 2019 |
| Contact name |
Qin Feng |
| E-mail(s) |
qfeng4@central.uh.edu
|
| Phone |
8328428824
|
| Organization name |
University of Houston
|
| Department |
Biology and Biochemistry
|
| Street address |
3517 Cullen Blvd
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77204 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL10739 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [probe set (exon) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA213138 |
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