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Series GSE48121 Query DataSets for GSE48121
Status Public on Jun 20, 2013
Title Expression data from human pancreatic cells PANC-1 infected with oncolytic vaccinia virus GLV-1h153
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Pancreatic cancer is a fatal disease associated with resistance to conventional therapies. GLV-1h153 is an oncolytic virus which has shown promise for the targeted treatment of cancer, and is engineered to carry the human sodium iodide symporter (hNIS) for the imaging of viral replication within tumors via enhanced uptake of several radionuclide probes.
We used microarrays to determine changes in gene expression patterns over time associated with infection and susceptibility of pancreatic cancer cells to GLV-1h153. Understanding into the molecular mechanisms associated with PANC-1 sensitivity to GLV-1h153 may enable identification of cancers resistant to viral therapy, avoid undesirable side effects associated with the need for higher doses of viral treatment, and development of safer and more efficacious oncolytic virotherapies.
Overall design PANC-1 cells were infected with GLV-1h153. Zero (T0), 6 (T6) and 24 (T24) hours after infection, 3 samples of each time point were harvested and gene expression patterns assessed using HG-U133A cDNA microarray chips as compared to uninfected control (T0).
Contributor(s) Haddad D, Szalay AA, Fong Y
Citation(s) 27119120
Submission date Jun 19, 2013
Last update date Dec 06, 2018
Contact name Dana Hadadd
Organization name Memorial Sloan-Kettering Cancer Center
Department Surgery
Lab Yuman Fong
Street address 410 E 69th st 4th floor
City New York
State/province NY
ZIP/Postal code 10019
Country USA
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (9)
GSM1168993 Uninfected PANC-1 cells rep1
GSM1168994 Uninfected PANC-1 cells rep2
GSM1168995 Uninfected PANC-1 cells rep3
BioProject PRJNA208954

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Supplementary file Size Download File type/resource
GSE48121_RAW.tar 17.4 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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